Benzoxazine isoquinolines as M4 selective muscarinic receptor antagonists

被引：0
|
作者：
Schwarz, RD
Boehme, TM
Augelli-Szafran, CE
Moreland, DW
机构：
[1] Pfizer Global Res & Dev, Ann Arbor Labs, Dept Neurosci Therapeut, Ann Arbor, MI USA
[2] Pfizer Global Res & Dev, Ann Arbor Labs, Dept Med Chem, Ann Arbor, MI USA
来源：
LIFE SCIENCES | 2001年 / 68卷 / 22-23期
关键词：
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
23
引用
收藏
页码：2626 / 2626
页数：1
相关论文
共 50 条
  • [41] Development of muscarinic m3 and m4 receptor antibodies with pharmacological activities
    Wang, HY
    Zeng, SJ
    Qiu, PX
    ACTA PHARMACOLOGICA SINICA, 1998, 19 (06): : 523 - 526
  • [42] Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist
    Spock, Matthew
    Carter, Trever R.
    Bollinger, Katrina A.
    Han, Changho
    Baker, Logan A.
    Rodriguez, Alice L.
    Peng, Li
    Dickerson, Jonathan W.
    Qi, Aidong
    Rook, Jerri M.
    O'Neill, Jordan C.
    Watson, Katherine J.
    Chang, Sichen
    Bridges, Thomas M.
    Engers, Julie L.
    Engers, Darren W.
    Niswender, Colleen M.
    Conn, P. Jeffrey
    Lindsley, Craig W.
    Bender, Aaron M.
    ACS MEDICINAL CHEMISTRY LETTERS, 2021, 12 (08): : 1342 - 1349
  • [43] Receptor internalization delays m4 muscarinic acetylcholine receptor resensitization at the plasma membrane
    Bogatkewitsch, GS
    Lenz, W
    Jakobs, KH
    vanKoppen, CJ
    MOLECULAR PHARMACOLOGY, 1996, 50 (02) : 424 - 429
  • [44] Synthesis and pharmacology of benzoxazines as highly selective antagonists M4 muscarinic receptors. (vol 45, pg 3096, 2002)
    Böhme, TM
    Augelli-Szafran, DE
    Hallak, H
    Pugsley, T
    Serpa, K
    Schwarz, RD
    JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (21) : 4800 - 4800
  • [45] Involvement of a Subpopulation of Neuronal M4 Muscarinic Acetylcholine Receptors in the Antipsychotic-like Effects of the M1/M4 Preferring Muscarinic Receptor Agonist Xanomeline
    Dencker, Ditte
    Wortwein, Gitta
    Weikop, Pia
    Jeon, Jongrye
    Thomsen, Morgane
    Sager, Thomas N.
    Mork, Arne
    Woldbye, David P. D.
    Wess, Juergen
    Fink-Jensen, Anders
    JOURNAL OF NEUROSCIENCE, 2011, 31 (16): : 5905 - 5908
  • [46] VISUALIZATION OF MUSCARINIC M4 MESSENGER-RNA AND M(4) RECEPTOR SUBTYPE IN RABBIT LUNG
    MAK, JCW
    HADDAD, EB
    BUCKLEY, NJ
    BARNES, PJ
    LIFE SCIENCES, 1993, 53 (19) : 1501 - 1508
  • [47] Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice
    Woolley, Marie L.
    Carter, Helen J.
    Gartlon, Jane E.
    Watson, Jeanette M.
    Dawson, Lee A.
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 603 (1-3) : 147 - 149
  • [48] Sulfide analogues as potent and selective M2 muscarinic receptor antagonists
    Wang, YG
    Chackalamannil, S
    Hu, ZY
    McKittrick, BA
    Greenlee, W
    Ruperto, V
    Duffy, RA
    Lachowicz, JE
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (07) : 1087 - 1091
  • [49] PRECLINICAL AND CLINICAL-PHARMACOLOGY OF SELECTIVE MUSCARINIC M(3) RECEPTOR ANTAGONISTS
    WALLIS, RM
    LIFE SCIENCES, 1995, 56 (11-12) : 861 - 868
  • [50] Analogues of oxybutynin as M3 selective muscarinic receptor antagonists.
    Sarma, PKS
    Kumar, N
    Kaur, K
    Chugh, A
    Gupta, S
    Dutt, A
    Gupta, JB
    Mehta, A
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U58 - U59
12345