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Enantiomeric composition of nicotine in smokeless tobacco, medicinal products, and commercial reagents
被引:3
|作者:
Armstrong, DW
[1
]
Wang, XD
[1
]
Ercal, N
[1
]
机构:
[1] Univ Missouri, Coll Arts & Sci, Dept Chem, Rolla, MO 65409 USA
来源:
关键词:
snuff;
chewing tobacco;
Turkish tobacco;
Burley tobacco;
Virginia tobacco;
transdermal patches;
gum;
nasal spray;
D O I:
10.1002/(SICI)1520-636X(1998)10:7<587::AID-CHIR6>3.0.CO;2-#
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
The enantiomeric composition of nicotine in 18 smokeless tobaccos, 3 strains of tobacco leaf, 8 pharmaceutical products, and 4 commercial reagents was determined. The relative amount of the minor enantiomeric component, (R)-(+)-nicotine, ranged from similar to 0.1% to similar to 1.2% of the total nicotine in all samples. In some cases it appears that (R)-(+)-nicotine may be considered one of the five most common alkaloids in tobacco products. The highest level of (R)-(+)-nicotine was found in a commercial transdermal patch. The extraction and purification processes used in obtaining commercial (S)-(-)-nicotine supplies from tobacco do not appear to decrease the amount of (R)-(+)-nicotine present. (C) 1998 Wiley-Liss, Inc.
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页码:587 / 591
页数:5
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