Enantiomeric composition of nicotine in smokeless tobacco, medicinal products, and commercial reagents

被引:3
|
作者
Armstrong, DW [1 ]
Wang, XD [1 ]
Ercal, N [1 ]
机构
[1] Univ Missouri, Coll Arts & Sci, Dept Chem, Rolla, MO 65409 USA
关键词
snuff; chewing tobacco; Turkish tobacco; Burley tobacco; Virginia tobacco; transdermal patches; gum; nasal spray;
D O I
10.1002/(SICI)1520-636X(1998)10:7<587::AID-CHIR6>3.0.CO;2-#
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The enantiomeric composition of nicotine in 18 smokeless tobaccos, 3 strains of tobacco leaf, 8 pharmaceutical products, and 4 commercial reagents was determined. The relative amount of the minor enantiomeric component, (R)-(+)-nicotine, ranged from similar to 0.1% to similar to 1.2% of the total nicotine in all samples. In some cases it appears that (R)-(+)-nicotine may be considered one of the five most common alkaloids in tobacco products. The highest level of (R)-(+)-nicotine was found in a commercial transdermal patch. The extraction and purification processes used in obtaining commercial (S)-(-)-nicotine supplies from tobacco do not appear to decrease the amount of (R)-(+)-nicotine present. (C) 1998 Wiley-Liss, Inc.
引用
收藏
页码:587 / 591
页数:5
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