Uncovering the differential impact of ESR1 and PIK3CA codon variants on the clinical phenotype of metastatic breast cancer (MBC) through circulating tumor DNA (ctDNA) next-generation sequencing (NGS).

被引：2

作者：

Gerratana, Lorenzo

Davis, Andrew A.

Velimirovic, Marko

D'Amico, Paolo

Shah, Ami N.

Clifton, Katherine

Zhang, Qiang

Dai, Charles Sichao

Reduzzi, Carolina

Hensing, Whitney L.

Bonotto, Marta

Mazzeo, Roberta

Wehbe, Firas Hazem

Franzoni, Alessandra

Belletti, Barbara

Behdad, Amir

Ma, Cynthia X.

Puglisi, Fabio

Bardia, Aditya

Cristofanilli, Massimo

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med Hematol & Oncol, Chicago, IL 60611 USA

[2] Univ Udine, Dept Med DAME, Chicago, IL USA

[3] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[4] Harvard Med Sch, Boston, MA 02115 USA

[5] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[6] Northwestern Univ, Chicago, IL 60611 USA

[7] Washington Univ, Sch Med, St Louis, MO 63110 USA

[8] Northwestern Univ, Lurie Canc Ctr, Div Hematol Oncol, Dept Med, Chicago, IL 60611 USA

[9] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[10] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA

[11] Univ Hosp Udine, Dept Oncol, Udine, Italy

[12] Univ Udine, Dept Med Area, Udine, Italy

[13] CRO Aviano, IRCCS, Dept Med Oncol, Udine, Italy

[14] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[15] Azienda Sanitaria Univ Friuli Cent ASUFC, Inst Human Genet, Udine, Italy

[16] IRCCS, Ctr Riferimento Oncol Aviano CRO, Unit Mol Oncol, Aviano, Italy

[17] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

[18] Univ Udine, Dept Med DAME, Udine, Italy

[19] IRCCS, Ctr Riferimento Oncol Aviano CRO, Dipartimento Oncol Med, Udine, Italy

[20] Harvard Med, Massachusetts Gen Hosp, Boston, MA USA

[21] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2021年 / 39卷 / 15期

关键词：

D O I：

10.1200/JCO.2021.39.15_suppl.1033

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1033

引用

页数：3

共 39 条

[21] Landscape of metastatic colorectal cancer (CRC) using comprehensive circulating tumor DNA (ctDNA) next-generation sequencing (NGS) in India: Expanding beyond RAS and RAF.
Rauthan, Amit
Lavingia, Viraj Kiran
Rohatgi, Nitesh
Bahl, Ankur
Dhar, Aparna
Sharma, Atul
Chugh, Bhuvan
Rajendranath, Rejiv
Patil, Shekar
Mohapatra, Prabrajya Narayan
Bharat, Rohit
Sandhir, Nippun
Joshi, Nisarg
Ostwal, Vikas S.
JOURNAL OF CLINICAL ONCOLOGY, 2025, 43 (4_SUPPL) : 49 - 49
[22] Incidence and outcomes among patients with HR+/HER2-metastatic breast cancer (mBC) with co-occurring ESR1 and PIK3CA mutations detected by ctDNA and treated with alpelisib: A retrospective review
Dempsey, Naomi
Chamorro, Yolcar
Tolman, Dana
Sandoval-Leon, Ana Cristina
Drusbosky, Leylah
Lewis, Courtney
Ahluwalia, Manmeet Singh
Mahtani, Reshma L.
JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
[23] Identifying the genomic and clinical features of AKT1/PIK3CA mutant metastatic prostate cancer using circulating tumor DNA
Herberts, Cameron M.
Murtha, Andrew J.
Fu, Simon
Wang, Gang
Schonlau, Elena
Gleave, Anna
Yip, Steven
Angeles, Arkhjamil
Hotte, Sebastien
Alshangiti, Abdulraheem
Tran, Ben
North, Scott
Taavitsainen, Sinja
Beja, Kevin
Vandekerkhove, Gillian
Ritch, Elie
Saad, Fred
Iqbal, Nayyer
Gleave, Martin E.
Annala, Matti
Chi, Kim N.
Wyatt, Alexander W.
CLINICAL CANCER RESEARCH, 2020, 26 (11) : 46 - 47
[24] Serial analysis of ESR1 and PIK3CA mutations in cell-free DNA from metastatic breast cancer during 1st line endocrine therapy
Baek, Soo Yeon
Hong, Meehyang
Lee, Seungah
Joo, Seulgi
Jang, JungPil
Jung, Chinkoo
Lee, Sae Byul
Yoo, Tae-Kyung
Chung, Il Yong
Kim, Hee Jeong
Ko, Beom Seok
Lee, Jong Won
Son, Byung Ho
Jeong, Hyehyun
Jeong, Jae Ho
Ahn, Jin-Hee
Jung, Kyung Hae
Kim, Sung-Bae
Lee, Hee Jin
Kim, Jisun
JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
[25] Estrogen receptor 1 (ESR1) mutations in circulating tumor DNA (ctDNA) from patients with ER+/HER2-metastatic breast cancer (mBC) treated with lasofoxifene or fulvestrant in the ELAINE 1 study
Goetz, Matthew P.
Gal-Yam, Einav
Stover, Daniel
Sammons, Sarah L.
Graff, Stephanie L.
Wang, Grace
Cristofanilli, Massimo
Riordan, Gary
Sloane, Hillary S.
Carroll, Dominic
Plourde, Paul V.
Portman, David J.
CANCER RESEARCH, 2023, 83 (05)
[26] Monitoring of PIK3CA and ESR1 mutations in circulating tumor DNA as predictive and prognostic biomarkers in patients with endocrine-resistant ER+/HER2-advanced breast cancer.
Fuentes Antras, Jesus
Garcia-Barberan, Vanesa
Gonzalo, Irene
Moreno, Fernando
Lopez-Cade, Igor
Ramirez-Ruda, Carmen
Bueno, Oskia
Ascaso del Rio, Ana
Pascual, Alejandro
Ocana, Alberto
Caldes, Trinidad
Angel Garcia-Saenz, Jose
JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
[27] Detection of TP53/PIK3CA Mutations in Cell-Free Plasma DNA From Metastatic Breast Cancer Patients Using Next Generation Sequencing
Nakauchi, Chiaki
Kagara, Naofumi
Shimazu, Kenzo
Shimomura, Atsushi
Naoi, Yasuto
Shimoda, Masafumi
Kim, Seung Jin
Noguchi, Shinzaburo
CLINICAL BREAST CANCER, 2016, 16 (05) : 418 - 423
[28] Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant (vol 28, pg 1500, 2022)
Tolaney, Sara M.
Toi, Masakazu
Neven, Patrick
Sohn, Joohyuk
Grischke, Eva-Maria
Llombart-Cussac, Antonio
Soliman, Hatem
Wang, Hong
Wijayawardana, Sameera
Jansen, Valerie M.
Litchfield, Lacey M.
Sledge, George W., Jr.
CLINICAL CANCER RESEARCH, 2022, 28 (20) : 4587 - 4587
[29] Clinical significance of PIK3CA, AKT1, and ESR1 mutation in plasma cell-free DNA from estrogen receptor-positive breast cancer patients
Takeshita, Takashi
Tomiguchi, Mai
Sueta, Aiko
Yamamoto-Ibusuki, Mutsuko
Yamamoto, Yutaka
Iwase, Hirotaka
CANCER RESEARCH, 2018, 78 (13)
[30] Estrogen receptor 1 (ESR1) mutations in circulating tumor DNA (ctDNA) from patients with ER+/HER2-metastatic breast cancer (mBC) treated with lasofoxifene plus abemaciclib in the ELAINE 2 study
Damodaran, Senthil
Moore, Halle
O'Sullivan, Ciara C.
Plourde, Paul V.
Riordan, Gary
Sloane, Hillary S.
Tripathy, Debu
Carroll, Dominic
Portman, David J.
CANCER RESEARCH, 2023, 83 (05)

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