Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis

被引：186

作者：

Friis, Stig D. ^{[1
]}

Pirnot, Michael T. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 27期

基金：

美国国家卫生研究院;

关键词：

CROSS-COUPLING REACTIONS; COOPERATIVE PALLADIUM/COPPER CATALYSIS; DUAL CATALYSIS; ORGANOMETALLIC REAGENTS; ARYL HALIDES; ALKENES; HYDROAMINATION; STYRENES; ESTERS; HYDROGENATION;

D O I：

10.1021/jacs.6b04566

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Detailed in this Communication is the enantioselective synthesis of 1,1-diarylalkanes, a structure found in a range of pharmaceutical drug agents and natural products, through the employment of copper(I) hydride and palladium catalysis. Judicious choice of ligand for both Cu and Pd enabled this hydroarylation protocol to work for an extensive array of aryl bromides and styrenes, including beta-substituted vinylarenes and six-membered heterocycles, under relatively mild conditions.

引用

页码：8372 / 8375

页数：4

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