Investigating direct routes to an advanced intermediate for the synthesis of C-20 diterpene alkaloids

被引：17
|
作者：
Williams, CM [1 ]
Mander, LN
Bernhardt, PV
Willis, AC
机构：
[1] Univ Queensland, Sch Mol & Microbial Sci, St Lucia, Qld 4072, Australia
[2] Australian Natl Univ, Res Sch Chem, Canberra, ACT, Australia
来源：
TETRAHEDRON | 2005年 / 61卷 / 15期
关键词：
diterpene alkaloids; silver (I); intramolecular Friedel-Crafts arylation; 3-azabicyclo[3.3.1]nonane;
D O I：
10.1016/j.tet.2005.02.014
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Rapid access to the ABCE ring system of the C-20 diterpene alkaloids was achieved by silver (I) promoted intramolecular Friedel-Crafts arylation of a functional group specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3759 / 3769
页数：11
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