HPLC determination of lorazepam and lorazepam-related compounds in pharmaceutical formulations

被引：3
|
作者：
Orlovic, D
Radulovic, D
Ivanovic, D
Vujic, Z
机构：
[1] Fac Pharm Belgrade, Dept Pharmaceut Chem & Drug Anal, YU-11000 Belgrade, Yugoslavia
[2] Zorka Pharma, YU-15000 Sabac, Yugoslavia
来源：
CHROMATOGRAPHIA | 2000年 / 52卷 / 11-12期
关键词：
column liquid chromatography; lorazepam pharmaceutical formulations; lorazepam-related compounds;
D O I：
10.1007/BF02490997
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A sensitive, accurate and reproducible high performance liquid chromatographic (HPLC) procedure has been developed for the separation and analysis of lorazepam and related compounds. A 20-muL sample was separated by reversed-phase HPLC on a 150 mm x 4.6 mm, 5-mum particle, Wakosil column with 0.1 M ammonium acetate (pH adjusted to 6.0 with acetic acid)-acetonitrile-methanol, 1:1:1 (v/v) as mobile phase.
引用
收藏
页码：732 / 734
页数：3
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