Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives

被引：6
|
作者：
Chen, Dong [1 ]
Zhai, Xin [1 ]
Yuan, Qiu Hui [1 ]
Luo, Jian [1 ]
Xie, Si Chang [1 ]
Gong, Ping [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Minist Educ, Key Lab Original New Drugs Design & Discovery, Shenyang 110016, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 11期
关键词：
1H-benzimidazol-5-ol; Synthesis; Anti-HBV activity;
D O I：
10.1016/j.cclet.2010.05.011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100 mu mol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg. (C) 2010 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1326 / 1329
页数：4
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