The bovine lung 20S proteasome binding to reversible inhibitors: modulation by sodium ion

被引：0

作者：

Eleuteri, AM ^{[1
]}

Angeletti, M ^{[1
]}

机构：

[1] Univ Camerino, Postgrad Sch Clin Biochim, Dept Mol Cellular & Anim Biol, I-62032 Camerino, MC, Italy

来源：

FEBS LETTERS | 2003年 / 547卷 / 1-3期

关键词：

20S proteasome; inhibition; sodium; linkage; signaling;

D O I：

10.1016/S0014-5793(03)00660-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of sodium ion on the inhibition exerted by Cbz-Leu-Leu-Leu-CHO on the chymotrypsin-like activity of the 20S proteasome isolated from bovine lung was investigated. The experimental data were analyzed using a standard linkage formalism. The calculated equilibrium affinity constants for the sodium ion binding to the free-enzyme and the inhibitor-bound enzyme are compatible to other well-characterized ion-involving heterotropic systems. The functional interdependence between the binding events played by the inhibitor and the sodium ion conforms to a heterotropic modulatory mechanism. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：7 / 10

页数：4

共 50 条

[31] The 20S proteasome of Streptomyces coelicolor
Nagy, I
Tamura, T
Vanderleyden, J
Baumeister, W
De Mot, R
JOURNAL OF BACTERIOLOGY, 1998, 180 (20) : 5448 - 5453
[32] Redox control of 20S proteasome
Friguet, B
Bulteau, AL
Conconi, M
Petropoulos, I
REDOX CELL BIOLOGY AND GENETICS, PT B, 2002, 353 : 253 - 262
[33] The Contribution of the 20S Proteasome to Proteostasis
Deshmukh, Fanindra Kumar
Yaffe, Dana
Olshina, Maya A.
Ben-Nissan, Gili
Sharon, Michal
BIOMOLECULES, 2019, 9 (05)
[34] Autocatalytic processing of the 20S proteasome
Seemuller, E
Lupas, A
Baumeister, W
NATURE, 1996, 382 (6590) : 468 - 470
[35] Structure and assembly of the 20S proteasome
W. L. H. Gerards
W. W. de Jong
W. Boelens
H. Bloemendal
Cellular and Molecular Life Sciences CMLS, 1998, 54 : 253 - 262
[36] Structure and assembly of the 20S proteasome
Gerards, WLH
de Jong, WW
Boelens, W
Bloemendal, H
CELLULAR AND MOLECULAR LIFE SCIENCES, 1998, 54 (03) : 253 - 262
[37] Modulation of the PA28α-20S proteasome interaction by a peptidyl alcohol
Wilk, S
Chen, WE
Magnusson, RP
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1999, 362 (02) : 283 - 290
[38] New Class of Proteasome 20S Inhibitors: a Crystallographic and Molecular Modelling Study
Ferretti, Valeria
Pretto, Loretta
Marastoni, Mauro
Baldisserotto, Anna
Gavioli, Riccardo
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2005, 61 : C273 - C273
[39] Synthesis of Salinosporamide A and Its Analogs as 20S Proteasome Inhibitors and SAR Summarization
Ma, Yuheng
Qu, Lili
Liu, Zhenming
Zhang, Liangren
Yang, Zhenjun
Zhang, Lihe
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2011, 11 (23) : 2906 - 2922
[40] New class of non-covalent inhibitors of the 20S proteasome.
Garcia-Echeverria, C
Imbach, P
France, D
Fürst, P
Guagnano, V
Lang, M
Noorani, M
Roesel, J
Scholz, D
Zimmermann, J
Furet, P
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U25 - U25

← 1 2 3 4 5 →