Regulation and biological function of the liver-specific miR-122

被引：108
|
作者：
Lewis, Andrew P. [1 ]
Jopling, Catherine L. [1 ]
机构：
[1] Univ Nottingham, Ctr Biomol Sci, Nottingham NG7 2RD, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2010年 / 38卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
cancer; circadian rhythm; hepatitis C virus; liver; microRNA (miRNA); miR; 122; IN-VIVO; MICRORNA; TRANSLATION; MODULATION; EXPRESSION; CANCER; RNAS;
D O I：
10.1042/BST0381553
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
miRNAs (microRNAs) are important regulators of gene expression In higher eukaryotes the tightly controlled expression of different miRNAs each of which regulates multiple target mRNAs is crucial for the maintenance of tissue type and the control of differentiation miR 122 is a highly lover specific miRNA that is important in hepatitis C virus infection cholesterol metabolism and hepatocellular carcinoma In the present review we discuss the effects of miR 122 on liver physiology and pathology Recent evidence of pathways involved in the regulation of miR 122 expression is also considered
引用
收藏
页码：1553 / 1557
页数：5
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