Visible-Light-Mediated Decarboxylative Benzylation of Imines with Arylacetic Acids

被引：32

作者：

Guo, Jing ^{[1
]}

Wu, Qiao-Lei ^{[1
]}

Xie, Ying ^{[1
]}

Weng, Jiang ^{[1
]}

Lu, Gui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 20期

关键词：

ALIPHATIC CARBOXYLIC-ACIDS; N-SULFONYL IMINES; C-H BONDS; PHOTOREDOX CATALYSIS; ALKYLATION; ALKENES; DERIVATIVES; 4-ALKYL-1,4-DIHYDROPYRIDINES; FUNCTIONALIZATION; FLUORINATION;

D O I：

10.1021/acs.joc.8b01849

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward method for the visible-light mediated decarboxylative benzylation of imines is reported. The key feature of this method is the use of simple primary, secondary, and tertiary arylacetic acids as precursors of benzyl radicals, enabling the facile benzylation of a variety of imines under mild conditions. A variety of structurally diverse beta-arylethylamines (37 examples) was accessed using this method.

引用

页码：12559 / 12567

页数：9

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