共 50 条
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
被引:9
|作者:
D'Onofrio, Nunzia
[1
]
Martino, Elisa
[1
]
Chianese, Giuseppina
[2
]
Coppola, Francesca
[3
]
Picariello, Luigi
[3
]
Moio, Luigi
[3
]
Balestrieri, Maria Luisa
[1
]
Gambuti, Angelita
[3
]
Forino, Martino
[3
]
机构:
[1] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via L De Crecchio 7, I-80138 Naples, Italy
[2] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy
[3] Univ Naples Federico II, Sect Vine & Wine Sci, Dept Agr Sci, I-83100 Avellino, Italy
关键词:
red wines;
polyphenols;
antioxidant;
insulin resistance;
hyperglycemia;
sirtuins;
INDUCED INSULIN-RESISTANCE;
CARDIOVASCULAR-DISEASE;
MEDITERRANEAN DIET;
SIGNALING PATHWAYS;
GRAPE CULTIVARS;
SULFUR-DIOXIDE;
ANTIOXIDANT;
BIOAVAILABILITY;
POLYPHENOLS;
GLUTATHIONE;
D O I:
10.3390/ijms22115677
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectrophotometric characterization showed that Magliocco was the richest wine in monomeric anthocyanins (two-fold), catechins, and low molecular weight phenolics (LMWP). A positive correlation was observed between the polyphenolic content and antioxidant capacity (p < 0.05), with Magliocco displaying the highest antioxidant capacity (p < 0.01). In vitro evidence on the endothelial cell models of insulin resistance and hyperglycemia showed the ability of Magliocco to reduce reactive oxygen species (ROS) (p < 0.01) and cytokine release (p < 0.01) and to upregulate SIRT1 and SIRT6 (p < 0.01). On the whole, the results indicated that the quantitative and qualitative phenolic profiles of red wines influence their in vitro beneficial effects on oxidative and proinflammatory milieu in endothelial cells, showing a positive modulation of SIRT1 and SIRT6, both implied in vascular aging.
引用
收藏
页数:19
相关论文