Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6

被引:9
|
作者
D'Onofrio, Nunzia [1 ]
Martino, Elisa [1 ]
Chianese, Giuseppina [2 ]
Coppola, Francesca [3 ]
Picariello, Luigi [3 ]
Moio, Luigi [3 ]
Balestrieri, Maria Luisa [1 ]
Gambuti, Angelita [3 ]
Forino, Martino [3 ]
机构
[1] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via L De Crecchio 7, I-80138 Naples, Italy
[2] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy
[3] Univ Naples Federico II, Sect Vine & Wine Sci, Dept Agr Sci, I-83100 Avellino, Italy
关键词
red wines; polyphenols; antioxidant; insulin resistance; hyperglycemia; sirtuins; INDUCED INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; SIGNALING PATHWAYS; GRAPE CULTIVARS; SULFUR-DIOXIDE; ANTIOXIDANT; BIOAVAILABILITY; POLYPHENOLS; GLUTATHIONE;
D O I
10.3390/ijms22115677
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectrophotometric characterization showed that Magliocco was the richest wine in monomeric anthocyanins (two-fold), catechins, and low molecular weight phenolics (LMWP). A positive correlation was observed between the polyphenolic content and antioxidant capacity (p < 0.05), with Magliocco displaying the highest antioxidant capacity (p < 0.01). In vitro evidence on the endothelial cell models of insulin resistance and hyperglycemia showed the ability of Magliocco to reduce reactive oxygen species (ROS) (p < 0.01) and cytokine release (p < 0.01) and to upregulate SIRT1 and SIRT6 (p < 0.01). On the whole, the results indicated that the quantitative and qualitative phenolic profiles of red wines influence their in vitro beneficial effects on oxidative and proinflammatory milieu in endothelial cells, showing a positive modulation of SIRT1 and SIRT6, both implied in vascular aging.
引用
收藏
页数:19
相关论文
共 50 条
  • [21] Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells
    Zhang, Weijin
    Huang, Qiaobing
    Zeng, Zhenhua
    Wu, Jie
    Zhang, Yaoyuan
    Chen, Zhongqing
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017, 2017
  • [22] Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease
    Maszlag-Torok, Rita
    Boros, Fanni A.
    Vecsei, Laszlo
    Klivenyi, Peter
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [23] Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson’s disease
    Rita Maszlag-Török
    Fanni A. Boros
    László Vécsei
    Péter Klivényi
    Scientific Reports, 11
  • [24] SIRT1、SIRT3、SIRT6和SIRT7调控肺纤维化机制的研究进展
    康弟
    李洪波
    中国呼吸与危重监护杂志, 2024, (01) : 64 - 68
  • [25] Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity
    Martinez-Jimenez, Veronica
    Cortez-Espinosa, Nancy
    Rodriguez-Varela, Eduardo
    Vega-Cardenas, Mariela
    Briones-Espinoza, Margarita
    Ruiz-Rodriguez, Victor M.
    Lopez-Lopez, Nallely
    Briseno-Medina, Armando
    Turijan-Espinoza, Eneida
    Portales-Perez, Diana P.
    DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2019, 13 (01) : 582 - 589
  • [26] Sirt6-Mediated Cell Death Associated with Sirt1 Suppression in Gastric Cancer
    Seo, Ji Hyun
    Ryu, Somi
    Cheon, So Young
    Lee, Seong-Jun
    Won, Seong-Jun
    Yim, Chae Dong
    Lee, Hyun-Jin
    Hah, Young-Sool
    Park, Jung Je
    CANCERS, 2024, 16 (02)
  • [27] SIRT1 controls endothelial angiogenic functions during vascular growth
    Potente, Michael
    Ghaeni, Laleh
    Baldessari, Danila
    Mostoslavsky, Raul
    Rossig, Lothar
    Dequiedt, Franck
    Haendeler, Judith
    Mione, Marina
    Dejana, Elisabetta
    Alt, Frederick W.
    Zeiher, Andreas M.
    Dimmeler, Stefanie
    GENES & DEVELOPMENT, 2007, 21 (20) : 2644 - 2658
  • [28] 抗衰老因子SIRT1和SIRT6抗衰老作用研究新进展
    阮清伟
    马骋
    陈洋
    马永兴
    中国老年学杂志, 2014, 34 (15) : 4387 - 4390
  • [29] SIRT6 inhibits endothelial-to-mesenchymal transition through attenuating the vascular endothelial inflammatory response
    Chen, Lifang
    Wang, Guan
    He, Jianyu
    Yang, Xin
    Zheng, Zihan
    Deng, Ying
    Liu, Yizhen
    Chen, Danli
    Lin, Rong
    Wang, Weirong
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 101
  • [30] SIRT1, SIRT2, SIRT6 and P21 gene expression in the lungs of mice chronically exposed to ambient particulate matter
    Mauad, Thais
    Ribeiro, Gabriel
    Veras, Mariana
    Costa, Natalia
    Shimada, Ana
    Alemany, Adair
    Mendes, Thais
    Saldiva, Paulo
    Farsky, Sandra
    EUROPEAN RESPIRATORY JOURNAL, 2014, 44