Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6

被引:9
|
作者
D'Onofrio, Nunzia [1 ]
Martino, Elisa [1 ]
Chianese, Giuseppina [2 ]
Coppola, Francesca [3 ]
Picariello, Luigi [3 ]
Moio, Luigi [3 ]
Balestrieri, Maria Luisa [1 ]
Gambuti, Angelita [3 ]
Forino, Martino [3 ]
机构
[1] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via L De Crecchio 7, I-80138 Naples, Italy
[2] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy
[3] Univ Naples Federico II, Sect Vine & Wine Sci, Dept Agr Sci, I-83100 Avellino, Italy
关键词
red wines; polyphenols; antioxidant; insulin resistance; hyperglycemia; sirtuins; INDUCED INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; SIGNALING PATHWAYS; GRAPE CULTIVARS; SULFUR-DIOXIDE; ANTIOXIDANT; BIOAVAILABILITY; POLYPHENOLS; GLUTATHIONE;
D O I
10.3390/ijms22115677
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectrophotometric characterization showed that Magliocco was the richest wine in monomeric anthocyanins (two-fold), catechins, and low molecular weight phenolics (LMWP). A positive correlation was observed between the polyphenolic content and antioxidant capacity (p < 0.05), with Magliocco displaying the highest antioxidant capacity (p < 0.01). In vitro evidence on the endothelial cell models of insulin resistance and hyperglycemia showed the ability of Magliocco to reduce reactive oxygen species (ROS) (p < 0.01) and cytokine release (p < 0.01) and to upregulate SIRT1 and SIRT6 (p < 0.01). On the whole, the results indicated that the quantitative and qualitative phenolic profiles of red wines influence their in vitro beneficial effects on oxidative and proinflammatory milieu in endothelial cells, showing a positive modulation of SIRT1 and SIRT6, both implied in vascular aging.
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页数:19
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