Impact of glucose tolerance status on the development of coronary artery disease among working-age men

被引：30
|
作者：
Fujihara, K. [1 ]
Igarashi, R. [1 ]
Yamamoto, M. [1 ]
Ishizawa, M. [2 ]
Matsubayasi, Y. [1 ]
Matsunaga, S. [1 ]
Kato, K. [1 ]
Ito, C. [2 ]
Koishi, M. [2 ]
Yamanaka, N. [2 ]
Kodama, S. [1 ]
Sone, H. [1 ]
机构：
[1] Niigata Univ, Fac Med, Dept Internal Med, 1-754 Asahimachi, Niigata, Niigata 9518510, Japan
[2] Japan Med Data Ctr Co Ltd, Tokyo, Japan
来源：
DIABETES & METABOLISM | 2017年 / 43卷 / 03期
关键词：
Coronary artery disease; Glucose tolerance status; Working-age men; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; RISK-FACTORS; WOMEN; COMPLICATIONS; DATABASE; COHORT;
D O I：
10.1016/j.diabet.2016.09.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims. To examine the impact of glucose tolerance status on the development of coronary artery disease (CAD) in working-age men in Japan. Methods. This population-based retrospective cohort study included 111,621 men aged 31-60 years [63,558 with normal glucose tolerance (NGT); 37,126 with prediabetes; 10,937 with diabetes]. The Cox proportional-hazards regression model was used to identify variables related to the incidence of CAD. Results. Multivariate analysis showed that, compared with NGT, diabetes increased the risk of CAD by 17.3 times (95% CI: 6.36-47.0) at ages 31-40 years, by 2.74 times (95% CI: 1.85-4.05) at ages 41-50 years and by 2.47 times (95% CI: 1.69-3.59) at ages 51-60 years. The HRs for CAD in men with diabetes aged 31-40 equaled that of men with NGT aged 51-60 [18.2 (7.15-46.4) and 19.4 (8.28-45.4), respectively]. Conclusion. The impact of diabetes on CAD was markedly greater in men aged 31-40 years compared with those aged 41-60 years. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：261 / 264
页数：4
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