Target Delivery of Daunorubicin to Glioblastoma by Cyclic RGD-Linked PEG-PLA Micelles

被引：13
|
作者：
Guan, Xingang [1 ]
Guan, Xinqiang [2 ]
Tong, Haibin [1 ]
Ma, Jun [3 ]
Sun, Xin [1 ]
机构：
[1] Beihua Univ, Life Sci Res Ctr, Fengman, Jilin Province, Peoples R China
[2] Lanzhou Univ, Hosp Affiliated 1, Dept Cardiothorac Surg, Lanzhou 730000, Gansu Province, Peoples R China
[3] Beihua Univ, Dept CT & MRI, Affiliated Hosp, Jilin, Jilin Province, Peoples R China
来源：
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2015年 / 52卷 / 05期
关键词：
polymer micelle; glioblastoma; RGD; Daunorubicin; target delivery; ANTITUMOR EFFICACY; NANOPARTICLES;
D O I：
10.1080/10601325.2015.1018816
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Daunorubicin (Dau) has been widely used in the treatment of many solid tumors. However, the side effects of Dau seriously hinder its further application in clinical use. How to increase the drug accumulation in tumors and reduce the damage to normal tissues is an urgent problem to be solved. In this study, we developed c(RGDfK) decorated PEG-PLA micelles for target delivery of Dau to C6 glioblastoma cells. The enhanced uptake of cRGD decorated micelles by C6 cells were observed via CLSM and flow cytometry experiments. Moreover, the cRGD decorated micelles showed more cytotoxicity to C6 cells than undecorated micelles ex vivo. Therefore, cRGD decorated micelles represent a promising approach in improving drug accumulation for treatment of glioblastoma.
引用
收藏
页码：401 / 406
页数：6
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