Selection of mutant strain of Penicillium funiculosum for (-)-mitorubrinic acid production

The strain of Penicillium funiculosum for the production of (-)-mitorubrinic acid was prepared hy mutation from the parental strain Penicillium funiculosum CCM F-8080 with production of (-)-mitorubrinic acid 175 mg/L. Ultraviolet radiation and N-nitroso-N-methyl-urea were used as mutagen agents. The mutant strain of Penicillium funiculosum was selected and the production of (-)-mitorubrinic acid increased from 443.4 to 728.7 mg/L. Also the mutant strain with blocked production of (-)-mitorubrinic acid and the strain with ability to produce some new orange metabolites were prepared.