Two-Dimensional Raman Correlation Analysis of Diseased Esophagus in a Rat

被引：1

作者：

Takanezawa, Sota ^{[1
,2
]}

Morita, Shin-ichi ^{[1
]}

Maruyama, Atsushi ^{[1
]}

Murakami, Takurou N. ^{[2
]}

Kawashima, Norimichi ^{[2
]}

Endo, Hiroyuki ^{[3
]}

Iijima, Katsunori ^{[3
]}

Asakura, Tohru ^{[3
]}

Shimosegawa, Tooru ^{[3
]}

Sato, Hidetoshi ^{[1
]}

机构：

[1] RIKEN, Condensed Mol Mat Lab, Wako, Saitama 3510198, Japan

[2] Toin Univ Yokohama, Dept Bioengn, Aoba Ku, Yokohama, Kanagawa 2250025, Japan

[3] Tohoku Univ, Grad Sch Med, Div Gastroenterol, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

APPLIED PHYSICS EXPRESS | 2010年 / 3卷 / 07期

关键词：

INFRARED-SPECTROSCOPY; MICROPROBE; VIBRATIONS; SPECTRA; FILMS; LENS;

D O I：

10.1143/APEX.3.077001

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Generalized two-dimensional (2D) Raman correlation analysis effectively distinguished a benign tumor from normal tissue. Line profiling Raman spectra of a rat esophagus, including a benign tumor, were measured and the generalized 2D synchronous and asynchronous spectra were calculated. In the autocorrelation area of the amide I band of proteins in the asynchronous map, a cross-like pattern was observed. A simulation study indicated that the pattern was caused by a sharp band component in the amide I band region. We considered that the benign tumor corresponded to the sharp component. (C) 2010 The Japan Society of Applied Physics

引用

页数：3

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