Spirocyclic oxetanes:: Synthesis and properties

被引：167

作者：

Wuitschik, Georg ^{[2
]}

Rogers-Evans, Mark ^{[1
]}

Buckl, Andreas

Bernasconi, Maurizio

Maerki, Moritz

Godel, Thierry ^{[1
]}

Fischer, Holger ^{[1
]}

Wagner, Bjoern ^{[1
]}

Parrilla, Isabelle ^{[1
]}

Schuler, Franz ^{[1
]}

Schneider, Josef ^{[1
]}

Alker, Andre ^{[1
]}

Schweizer, W. Bernd

Mueller, Klaus ^{[1
]}

Carreira, Erick M. ^{[2
]}

机构：

[1] F Hoffmann La Roche & Cie AG, Div Pharmaceut, CH-4070 Basel, Switzerland

[2] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 24期

关键词：

carbonyl compounds; heterocycles; morpholine; oxetanes; spiro compounds;

D O I：

10.1002/anie.200800450

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Presented) Wormholes through chemical space: Spirocyclic oxetanes are described as analogues of morpholine and also as topological siblings of their carbonyl counterparts. They are particularly promising in terms of both their physicochemical properties and the ease with which they can be grafted onto molecular structures. The data collected highlight oxetanes as both the hydrophilic sister of a gem-dimethyl unit and the carbonyl group's lipophilic brother. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4512 / 4515

页数：4

共 50 条

[31] Advances in the Synthesis of Spirocyclic Nucleosides
Kumar, Sumit
Khan, Yousuf
Arora, Aditi
Kumar, Manish
Rungta, Pallavi
Singh, Brajendra K.
Sharma, Vivek K.
Singh, Sunil K.
SYNTHESIS-STUTTGART, 2024, 56 (07): : 1097 - 1138
[32] Synthesis of α-spirocyclic pyrrolidines (microreview)
Melnykov, Kostiantyn P.
Ryabukhin, Sergey V.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2020, 56 (11) : 1411 - 1413
[33] SYNTHESIS OF SPIROCYCLIC AMINOHYDRAZINOCYCLOTRIPHOSPHAZENES AND DIHYDRAZINOCYCLOTRIPHOSPHAZENES
GOLDIN, GS
BATURINA, LS
NOVIKOVA, AN
FEDOROV, SG
ZHURNAL OBSHCHEI KHIMII, 1975, 45 (11): : 2566 - 2567
[34] Synthesis of diarylcyclopropyl spirocyclic ketones
Chang, Meng-Yang
Chan, Chieh-Kai
Chen, Yi-Chia
TETRAHEDRON, 2014, 70 (15) : 2529 - 2536
[35] Oxetanes as Versatile Elements in Drug Discovery and Synthesis
Burkhard, Johannes A.
Wuitschik, Georg
Rogers-Evans, Mark
Mueller, Klaus
Carreira, Erick M.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (48) : 9052 - 9067
[36] Synthesis and application of new types of fluorinated oxetanes
Deng, Yufei
Zou, Yingquan
PROGRESS IN ORGANIC COATINGS, 2020, 143
[37] SYNTHESIS OF OXETANES WITH PERFLUORINATED-ALKYL SUBSTITUENTS
LANIER, M
PASTOR, R
RIESS, JG
TETRAHEDRON LETTERS, 1993, 34 (32) : 5093 - 5094
[38] PHOTOCHEMICAL SYNTHESIS OF OXETANES FROM DIETHYL OXALATE
TOMINAGA, T
ODAIRA, Y
TSUTSUMI, S
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1967, 40 (10) : 2451 - +
[39] Synthesis of a spirocyclic indoline lactone
Hodges, JC
Wang, W
Riley, F
JOURNAL OF ORGANIC CHEMISTRY, 2004, 69 (07): : 2504 - 2508
[40] Synthesis and Antiviral Properties of Spirocyclic [1,2,3]-Triazolooxazine Nucleosides
Dell'Isola, Antonio
McLachlan, Matthew M. W.
Neuman, Benjamin W.
Al-Mullah, Hawaa M. N.
Binks, Alexander W. D.
Elvidge, Warren
Shankland, Kenneth
Cobb, Alexander J. A.
CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (37) : 11685 - 11689

← 1 2 3 4 5 →