Green polymer chemistry: Precision synthesis of novel multifunctional poly(ethylene glycol)s using enzymatic catalysis

被引：37
|
作者：
Puskas, Judit E. [1 ]
Seo, Kwang Su [1 ]
Sen, Mustafa Y. [1 ]
机构：
[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA
来源：
EUROPEAN POLYMER JOURNAL | 2011年 / 47卷 / 04期
基金：
美国国家科学基金会;
关键词：
Green chemistry; Enzymes; Poly(ethylene glycol); Functionalization; Dendrimer; IRREVERSIBLE ACYL TRANSFER; MICHAEL ADDITION; BIOMEDICAL APPLICATIONS; STAR POLYISOPRENES; ORGANIC-SOLVENTS; LIPASE CATALYSIS; TRANSFER AGENTS; DRUG-DELIVERY; DENDRIMERS; TRANSESTERIFICATION;
D O I：
10.1016/j.eurpolymj.2010.10.015
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This paper gives an overview about enzyme catalysis, and reports the precision synthesis of multifunctional poly(ethylene glycol)s using this green chemistry approach. Specifically, vinyl acrylate was transesterified with tetraethylene glycol (TEG) and a PEG with DPn = 23, and then (HO)(2)-TEG-(OH)(2) and (HO)(2)-PEG-(OH)(2) were synthesized by the Michael addition of diethanolamine to the acrylate double bonds. These structures will serve as the core of novel dendrimers designed for drug delivery applications. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：524 / 534
页数：11
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