Synthesis and evaluation of antibacterial and antibiofilm activities of pyridin-2-yl hexanoate

被引：2

作者：

Kouidhi, Bochra ^{[1
]}

Hagar, Mohamed ^{[2
,3
]}

Radwan, Nagi R. E. ^{[2
,4
]}

Chaieb, Kamel ^{[5
]}

机构：

[1] Yanbu el Baher Taibah Univ, Coll Appl Med Sci, Med Lab Dept, Yanbu, Saudi Arabia

[2] Yanbu el Baher Taibah Univ, Chem Dept, Coll Sci, Yanbu, Saudi Arabia

[3] Alexandria Univ, Chem Dept, Fac Sci, Alexandria, Egypt

[4] Suez Univ, Chem Dept, Fac Sci, Suez, Egypt

[5] Monastir Univ, Fac Pharm, Lab Anal Treatment & Valorizat Pollutants Environ, Monastir, Tunisia

来源：

MICROBIAL PATHOGENESIS | 2018年 / 125卷

关键词：

Pyridin-2-yl hexanoate; Antibacterial; XTT assay; Antibiofilm; BIOFILMS; CYTOTOXICITY; DERIVATIVES; INHIBITION; CHEMISTRY; RING;

D O I：

10.1016/j.micpath.2018.09.022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Synthesized Pyridin-2-yl hexanoate was screened for its antibacterial and antibiofilm activities using the broth microdilution method and XTT assay respectively. The obtained results revealed that synthesized molecule inhibited the growth of pathogenic bacteria (MICs value ranged from 80 to 640 mu g ml(-1)). Moreover, it induced a strong antibiofilm effect against Gram positive cocci (BIC50 was 366, 378 and 412 mu g ml(-1) for Streptococcus mutans ATCC 25175, Streptococcus salivarius ATCC 13419 and Streptococcus oralis ATCC 6249 respectively). Basis on these results, pyridin-2-yl hexanoate may be considered as effective compound with antibacterial and antibiofilm activities.

引用

页码：205 / 209

页数：5

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