Retrospective Cohort Study of COVID-19 in Patients of the Brazilian Public Health System with SARS-CoV-2 Omicron Variant Infection

被引：3

作者：

Murari, Thiago B. ^{[1
]}

Dos Santos Fonseca, Larissa Moraes ^{[1
,2
]}

Pereira, Hernane B. de B. ^{[1
,3
]}

Nascimento Filho, Aloisio S. ^{[1
]}

Saba, Hugo ^{[1
,3
]}

Scorza, Fulvio A. ^{[4
]}

de Almeida, Antonio-Carlos G. ^{[5
]}

Maciel, Ethel L. N. ^{[6
]}

Mendes, Jose F. F. ^{[7
,8
]}

Rocha Filho, Tarcisio M. ^{[9
,10
]}

David, John R. ^{[11
,12
]}

Badaro, Roberto ^{[1
,2
]}

Souza Machado, Bruna Aparecida ^{[1
,2
]}

Moret, Marcelo A. ^{[1
,3
]}

机构：

[1] Univ Ctr SENAI CIMATEC, Modelagem Computac, BR-41650010 Salvador, BA, Brazil

[2] Univ Ctr SENAI CIMATEC, SENAI Inst Innovat ISI Hlth Adv Syst, BR-41650010 Salvador, BA, Brazil

[3] Univ Estado Bahia, Dept Ciencias Exatas & Terra, BR-41150000 Salvador, BA, Brazil

[4] Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Disciplina Neurociencia, BR-04021001 Sao Paulo, SP, Brazil

[5] Univ Fed Sao Joao del Rei UFSJ, Dept Engn Biossistemas, BR-36307352 Sao Joao Del Rei, MG, Brazil

[6] Univ Fed Espirito Santo, Lab Epidemiol, BR-29075910 Vitoria, ES, Brazil

[7] Univ Aveiro, Dept Fis, P-3880 Aveiro, Portugal

[8] Univ Aveiro, I3N, P-3880 Aveiro, Portugal

[9] Univ Brasilia, Int Ctr Condensed Matter Phys, BR-70910900 Brasilia, DF, Brazil

[10] Univ Brasilia, Inst Fis, BR-70910900 Brasilia, DF, Brazil

[11] Harvard TH Chan Sch Publ Hlth, Fac Publ Hlth, Boston, MA 02115 USA

[12] Harvard Med Sch, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

VACCINES | 2022年 / 10卷 / 09期

关键词：

booster; vaccine effectiveness; COVID-19; VACCINATION; IMPACT;

D O I：

10.3390/vaccines10091504

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several vaccines against COVID-19 are now available, based on different techniques and made by different laboratories spread around the world. With the roll out of the vaccination process in an advanced stage in many countries, the reduced risk of hospitalization due to the Omicron variant relative to the Delta variant infection, despite the higher transmission risk of Omicron, may lead to a misinterpretation of the results, as infection by Omicron is associated with a significant reduction in severe outcomes and shorter hospitalization time than the Delta variant. We compared the in-hospital mortality due to the Omicron (Jan-Mar 2022) with Gamma (Jan 2021) and Delta (Oct-Dec 2021) variants of patients in the Brazilian public health system. This study also discusses the decrease in booster vaccine effectiveness in patients hospitalized due to the Omicron variant compared with the Delta variant. Without a remodeling of vaccines for new variants, booster doses may be necessary with a shorter time interval.

引用

页数：11

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