Hyphenated LC-ICP-MS/ESI-MS Identification of Halogenated Metabolites in South African Marine Ascidian Extracts

被引：5
|
作者：
Bromley, Candice L. [1 ]
Raab, Andrea [2 ]
Parker-Nance, Shirley [3 ]
Beukes, Denzil R. [4 ]
Jaspars, Marcel [2 ]
Davies-Coleman, Michael T. [5 ]
机构：
[1] Rhodes Univ, Dept Chem, ZA-6140 Grahamstown, South Africa
[2] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Old Aberdeen AB24 3UE, Scotland
[3] Nelson Mandela Metropolitan Univ, Dept Zool, POB 77000, ZA-6031 Port Elizabeth, South Africa
[4] Univ Western Cape, Sch Pharm, ZA-7535 Bellville, South Africa
[5] Univ Western Cape, Dept Chem, ZA-7535 Bellville, South Africa
来源：
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2018年 / 71卷
基金：
新加坡国家研究基金会;
关键词：
Marine; ascidian; iodinated tyramine; iodinated tyrosine; LC-ICP-MS/ESI-MS; LISSOCLINUM-PATELLA METABOLITES; DIDEMNUM-RUBEUM; METAL-BINDING; PLAKINIDINE D; DERIVATIVES; PRODUCTS; TUNICATE; SPONGES; IODINE;
D O I：
10.17159/0379-4350/2018/v71a14
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Extracts of 13 species of marine ascidian collected in Algoa Bay were analyzed by LC-ICP-MS/ESI-MS. This technique allows parallel analysis of the molecular species and the presence of certain elements. The LC-ICP-MS/ESI-MS technique was used to target iodinated metabolites in this study. Three ascidian species afforded the known 3,5-diiodo-4-methoxyphenethylamine (12), which was confirmed by the isolation of this metabolite from Aplidium monile. MS also suggested the presence of the known 3,5-datromo-4-methoxyphenethylamine (10) and the new 3-bromo-5-iodo-4-methoxyphenethylamine (11) in the A. monile extract. The presence of the known 3,5-dibromotetramethyltyrosine (21) and the new 3-iodotetramethyltyrosine (23) in extracts of an unidentified Didemnum species was similarly proposed from MS evidence. This is the first report of the occurrence of iodinated metabolites in South African marine invertebrates.
引用
收藏
页码：111 / 117
页数：7
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