Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature

被引：34

作者：

Wuerth, Roberto ^{[1
]}

Barbieri, Federica ^{[1
,4
]}

Bajetto, Adriana ^{[1
,4
]}

Pattarozzi, Alessandra ^{[1
]}

Gatti, Monica ^{[1
]}

Porcile, Carola ^{[1
]}

Zona, Gianluigi ^{[2
,4
]}

Ravetti, Jean-Louis ^{[3
]}

Spaziante, Renato ^{[2
,4
]}

Florio, Tullio ^{[1
,4
]}

机构：

[1] Univ Genoa, Pharmacol Lab, Dept Oncol Biol & Genet, I-16132 Genoa, Italy

[2] Univ Genoa, Div Neurosurg, Dept Neurosci Ophthalmol & Genet, I-16132 Genoa, Italy

[3] San Martino Hosp, Sect Pathol, I-16132 Genoa, Italy

[4] GSCTC, I-16132 Genoa, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 234卷 / 1-2期

关键词：

Meningioma; CXCL11; CXCL12; CXCR4; CXCR7; SIGNAL-REGULATED KINASES-1/2; ENDOTHELIAL-CELLS; TUMOR-GROWTH; IN-VIVO; PROLIFERATION; SDF1; FACTOR-1-ALPHA; LOCALIZATION; ANGIOGENESIS; RECURRENCE;

D O I：

10.1016/j.jneuroim.2011.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CXCR4 and CXCR7 chemokine receptors, and their ligands CXCL11 and CXCL12, have been often involved in tumor cell proliferation and survival. We report the expression pattern of these ligand/receptor pairs in 22 human meningiomas. High CXCR7 and CXCL12 expression was associated with high-proliferative tumors. CXCR7 levels were correlated to the content of both ligands, suggesting a possible autocrine regulation. CXCR4 and CXCL12 were homogeneously expressed within tumor cells, while CXCR7 was mainly detected in tumor endothelial cells and CXCL11 in pericytes. Our results highlight the preferential CXCR7 and CXCL12 expression within more aggressive tumors and the possible role of CXCR7 in meningioma vascularization. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：115 / 123

页数：9

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