Crystal structures of GCN2 C-terminal domain: Insight into GCN2 regulation

被引:0
|
作者
Singh, I. [1 ]
He, H. [1 ]
Wek, S. [1 ]
Dey, S. [1 ]
Baird, T. [1 ]
Wek, R. [1 ]
Georgiadis, M. [1 ,2 ]
机构
[1] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA
[2] Indiana Univ Purdue Univ, Dept Chem & Chem Biol, Indianapolis, IN 46202 USA
关键词
GCN2; Translation attenuation; RNA binding;
D O I
10.1107/S2053273314085921
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
MS93.P12
引用
收藏
页码:C1407 / C1407
页数:1
相关论文
共 50 条
  • [41] Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2
    Ciudad, M. Teresa
    Quevedo, Rene
    Lamorte, Sara
    Jin, Robbie
    Nzirorera, Nadine
    Koritzinsky, Marianne
    McGaha, Tracy L.
    CANCER RESEARCH COMMUNICATIONS, 2024, 4 (03): : 765 - 784
  • [42] Starving Intestinal Inflammation with the Amino Acid Sensor GCN2
    Revelo, Xavier S.
    Winer, Shawn
    Winer, Daniel A.
    CELL METABOLISM, 2016, 23 (05) : 763 - 765
  • [43] Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK
    Anderson, B. R.
    Kariko, K.
    Weissman, D.
    GENE THERAPY, 2013, 20 (02) : 136 - 142
  • [44] GCN2 activation and eIF2α phosphorylation in the maturation of mouse oocytes
    Alves, Viviane S.
    Motta, Fabiana L.
    Roffe, Martin
    Delamano, Arthur
    Pesquero, Joao B.
    Castilho, Beatriz A.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 378 (01) : 41 - 44
  • [45] GCN2, a Type 2 Diabetes Mellitus Susceptibility Gene, Is Associated with the Regulation of Pancreatic β-Cell Mass
    Kanno, Ayumi
    Masuda, Katsuhisa
    Asahara, Shun-Ichiro
    Kimura, Maki
    Matsuda, Tomokazu
    Kasuga, Masato
    Ogawa, Wataru
    Seino, Susumu
    Kido, Yoshiaki
    DIABETES, 2015, 64 : A599 - A599
  • [46] The role of the IMPACT/GCN1/GCN2 translational control module in pancreatic adenocarcinoma.
    Bellis, Barbara
    Begnami, Maria Dirlei
    Freitas, Helano Carioca
    Martins, Vilma Regina
    Roffe, Martin
    Maroso Hajj, Glaucia Noeli
    CLINICAL CANCER RESEARCH, 2018, 24 (01) : 101 - 101
  • [47] Arabidopsis GCN2 kinase contributes to ABA homeostasis and stomatal immunity
    Xiaoyu Liu
    Taiaba Afrin
    Karolina M. Pajerowska-Mukhtar
    Communications Biology, 2
  • [48] Increased Susceptibility to DNA Virus Infection in Mice with a GCN2 Mutation
    Won, Sungyong
    Eidenschenk, Celine
    Arnold, Carrie N.
    Siggs, Owen M.
    Sun, Lei
    Brandl, Katharina
    Mullen, Tina-Marie
    Nemerow, Glen R.
    Moresco, Eva Marie Y.
    Beutler, Bruce
    JOURNAL OF VIROLOGY, 2012, 86 (03) : 1802 - 1808
  • [49] GCN2 adapts protein synthesis to scavenging-dependent growth
    Nofal, Michel
    Wang, Tim
    Yang, Lifeng
    Jankowski, Connor S. R.
    Li, Sophia Hsin-Jung
    Han, Seunghun
    Parsons, Lance
    Frese, Alexander N.
    Gitai, Zemer
    Anthony, Tracy G.
    Wuhr, Martin
    Sabatini, David M.
    Rabinowitz, Joshua D.
    CELL SYSTEMS, 2022, 13 (02) : 158 - +
  • [50] GCN2 kinase activation by ATP-competitive kinase inhibitors
    Colin P. Tang
    Owen Clark
    John R. Ferrarone
    Carl Campos
    Alshad S. Lalani
    John D. Chodera
    Andrew M. Intlekofer
    Olivier Elemento
    Ingo K. Mellinghoff
    Nature Chemical Biology, 2022, 18 : 207 - 215