One-Pot Synthesis of Benzene and Pyridine Derivatives via Copper-Catalyzed Coupling Reactions

被引：44

作者：

Han, Jianwei ^{[1
,2
]}

Guo, Xin ^{[1
,2
]}

Liu, Yafeng ^{[1
,2
]}

Fu, Yajie ^{[1
,2
]}

Yan, Rulong ^{[1
,2
]}

Chen, Baohua ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 15期

基金：

美国国家科学基金会;

关键词：

polysubstituted pyridine; copper-catalyzed; polysubstituted benzene; acetophenones; toluene derivatives; SUBSTITUTED PYRIDINES; POLYSUBSTITUTED PYRIDINES; SYMMETRICAL PYRIDINES; KETOXIME ACETATES; BOND-CLEAVAGE; CYCLIZATION; ALDEHYDES; ACTIVATION; AMINATION; ARYLATION;

D O I：

10.1002/adsc.201700053

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A highly efficient one-pot synthesis of polysubstituted pyridine has been achieved through copper-catalyzed oxidative sp(3) C-H coupling of acetophenones with toluene derivatives. Besides, the polysubstituted benzene was obtained through copper-catalyzed coupling of acetophenones. Both of the reactions exhibited a good functional group tolerance to produce a 2,4,6-triphenylpyridine or 1,3,5-triarylbenzene in high yields. Compared with previous methods, these transformations allow a highly flexible and efficient preparation of substituted pyridines and benzenes.

引用

页码：2676 / 2681

页数：6

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