Molecular docking studies on pyridine derivatives of glitazones as PPARγ agonists

被引：0
|
作者：
Bharatam, PV [1 ]
Khanna, S [1 ]
机构：
[1] NIPER, Dept Med Chem, Mohali 160062, Punjab, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY | 2006年 / 45卷 / 01期
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暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
FlexX software has been employed to perform molecular docking analysis on a series of glitazones in the active site of PPAR gamma. FlexX scores and interaction energies of glitazones have been compared with I those of the corresponding pyridine analogs. The results point out that the binding affinities do not significantly change due to the benzene versus pyridine substitution in the central ring of PPAR gamma. The experimentally observed differences do not originate from the differences in the binding affinities.
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页码：188 / 193
页数：6
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