Histone Deacetylase Inhibitors: Synthesis of Tetrapeptide Analogue SAHA/TPX

被引：1

作者：

Ekou, Lynda ^{[1
]}

Ekou, Tchirioua ^{[1
]}

Opalinski, Isabelle ^{[2
]}

Gesson, Jean Pierre ^{[2
]}

机构：

[1] Univ Abobo Adjame, Lab Thermodynam & Physicochim Milieu, Abidjan 02, Cote Ivoire

[2] Univ Poitiers, UMR CNRS 6514, Lab Synth & Reactivite Subst Nat, F-86022 Poitiers, France

来源：

E-JOURNAL OF CHEMISTRY | 2011年 / 8卷

关键词：

Histone deacetylase inhibitors; Tetrapeptide; Hydroxamic acid; TRANSFORMED-CELL DIFFERENTIATION; CYCLIC TETRAPEPTIDE; HDAC INHIBITORS; TRICHOSTATIN-A; INDUCERS; TRAPOXIN; CANCER; LENGTH; TARGET;

D O I：

10.1155/2011/572546

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The inhibition of HDAC (histone deacetylase) activity by specific inhibitors induces growth arrest, differentiation and apoptosis of transformed or several cancer cells. Some of these inhibitors are in clinical trial at phase I or phase II. The discovery and development of specific HDAC inhibitors are helpful for cancer therapy. In this paper we describe the synthesis of simple inhibitor B hybrid analogue suberoylanilide hydroxamic acid (SAHA), trapoxin B (TPX B) in as little as five steps. This compound is interesting lead for the design of potent inhibitors of histone deacetylase.

引用

页码：S79 / S84

页数：6

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