Left ventricular (LV) pacing in newborns and infants: Echo assessment of LV systolic function and synchrony at 5-year follow-up

被引:12
|
作者
Silvetti, Massimo Stefano [1 ]
Muzi, Giulia [1 ]
Unolt, Marta [1 ]
D'Anna, Carolina [1 ]
Saputo, Fabio Anselmo [1 ]
Di Mambro, Corrado [1 ]
Albanese, Sonia [2 ]
Ammirati, Antonio [1 ]
Rava, Lucilla [3 ]
Drago, Fabrizio [1 ]
机构
[1] Bambino Gesu Childrens Hosp & Res Inst, Dept Pediat Cardiol & Cardiac Surg, Pediat Cardiol & Cardiac Arrhythmias Unit, Rome, Italy
[2] Bambino Gesu Childrens Hosp & Res Inst, Cardiac Surg Unit, Rome, Italy
[3] Bambino Gesu Childrens Hosp & Res Inst, Epidemiol Unit, Rome, Italy
来源
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY | 2020年 / 43卷 / 06期
关键词
alternative pacing sites; cardiac pacing; children; congenital atrioventricular block; heart failure; CARDIAC RESYNCHRONIZATION THERAPY; CONGENITAL HEART-DISEASE; ATRIOVENTRICULAR-BLOCK; DILATED CARDIOMYOPATHY; CHILDREN; SITE; STRAIN;
D O I
10.1111/pace.13908
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Small retrospective studies reported that left ventricular (LV) pacing is likely to preserve LV function in children with isolated congenital complete atrioventricular block (CCAVB). The aim of this study was to prospectively evaluate LV contractility and synchrony in a cohort of neonates/infants at pacemaker implantation and follow-up. Methods Patients with CCAVB who underwent LV pacing were evaluated with electrocardiogram and echocardiogram in a single-center, prospective study. Data were collected at implantation, at 1-month and every year of follow-up, up to 5 years. LV ventricular dimensions (diameters and volumes), systolic function (ejection fraction [EF] and global longitudinal strain [GLS]), and synchrony were evaluated. Data are reported as median (25th-75th centiles). Results Twenty consecutive patients with CCAVB underwent pacemaker implantation (12 single-chamber pacemaker [VVIR] and eight dual-chamber pacemaker [DDD]) with epicardial leads: 17 on the LV apex and three on the free wall. Age at implantation was 0.3 months (1 day-4.5 months). Patients showed good clinical status, normal LV dimensions, preserved systolic function, and synchrony at 60 (30-60) months follow-up. EF increased to normal values in patients with preimplantation EF <50%. Presence of antibodies and pacing mode (DDD vs VVIR) had no impact on the outcome. Conclusions LV pacing preserved LV systolic function and synchrony in neonates and infants with CCAVB at 5-year follow-up. LV EF improved in patients with low preimplantation EF. Pacing mode or the presence of autoantibodies did not demonstrated an impact on LV contractility and synchrony.
引用
收藏
页码:535 / 541
页数:7
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