Important Role of Oxidative Stress Biomarkers in Huntington's Disease

被引：72

作者：

Tunez, Isaac ^{[1
]}

Sanchez-Lopez, Fernando ^{[2
]}

Agueera, Eduardo ^{[2
]}

Fernandez-Bolanos, Ricardo ^{[3
]}

Manuel Sanchez, Francisco ^{[3
]}

Tasset-Cuevan, Inmaculada ^{[1
]}

机构：

[1] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Fac Med, Dept Bioquim & Biol Mol, Cordoba, Spain

[2] Hosp Univ Reina Sofia Cordoba, IMIBIC, Serv Neurol, Cordoba, Spain

[3] Hosp Univ Nuestra Senora Valme, Serv Neurol, Seville, Spain

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 15期

关键词：

GLUTATHIONE-PEROXIDASE ACTIVITIES; SUPEROXIDE-DISMUTASE; BLOOD; BRAIN;

D O I：

10.1021/jm200605a

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.

引用

页码：5602 / 5606

页数：5

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