Successful Salvage Chemotherapy with Gemcitabine and Vinorelbine in a Malignant Pleural Mesothelioma Patient Previously Treated with Pemetrexed

被引:0
|
作者
Agatsuma, Toshihiko [1 ]
Koizumi, Tomonobu [2 ]
Yasuo, Masanori [1 ]
Urushihata, Kazuhisa [1 ]
Tsushima, Kenji [1 ]
Yamamoto, Hiroshi [1 ]
Hanaoka, Masayuki [1 ]
Fukushima, Mana [3 ]
Honda, Takayuki [3 ]
Kubo, Keishi [1 ]
机构
[1] Shinshu Univ, Sch Med, Dept Internal Med 1, Matsumoto, Nagano 3908621, Japan
[2] Shinshu Univ Hosp, Ctr Comprehens Canc, Div Clin Oncol, Matsumoto, Nagano, Japan
[3] Shinshu Univ, Sch Med, Dept Lab Med, Matsumoto, Nagano 390, Japan
关键词
malignant pleural mesothelioma; salvage chemotherapy; gemcitabine; vinorelbine; MULTICENTER PHASE-II; CISPLATIN; TRIAL;
D O I
10.1093/jjco/hyq101
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The role of second-line and salvage chemotherapy in malignant pleural mesothelioma treatment is not yet established. We report a case of relapsed malignant pleural mesothelioma in which the patient failed to respond to pemetrexed-based chemotherapy but was successfully treated with gemcitabine and vinorelbine. The patient underwent a left extrapleural pneumonectomy. Three years later she developed anterior chest wall and retroperitoneal masses. Histological findings revealed metastases from the malignant pleural mesothelioma. Although two cycles of carboplatin plus pemetrexed chemotherapy were administered, she had progressive disease. Then, 1000 mg/m(2) gemcitabine and 25 mg/m(2) vinorelbine were administered every 2 weeks. The chemotherapy regimen was tolerated well, and the tumors were remarkably reduced. She was treated with 12 cycles of gemcitabine plus vinorelbine, and 8.5 months of progression-free survival was observed. Gemcitabine plus vinorelbine chemotherapy may be a candidate regimen for salvage chemotherapy against malignant pleural mesotheliomas.
引用
收藏
页码:1180 / 1183
页数:4
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