A mild halogenation of pyrazoles using sodium halide salts and Oxone

被引：25
|
作者：
Olsen, Kathryn L. [1 ]
Jensen, Matthew R. [1 ]
MacKay, James A. [1 ]
机构：
[1] Elizabethtown Coll, Dept Chem & Biochem, 1 Alpha Dr, Elizabethtown, PA 17022 USA
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 43期
关键词：
Pyrazole; Halogenation; Oxone; Green chemistry; HOFMANN REARRANGEMENT; N-HALOSUCCINIMIDES; TERMINAL OXIDANT; EFFICIENT METHOD; IN-SITU; OXIDATION; WATER; ACIDS; BROMINATION; IRRADIATION;
D O I：
10.1016/j.tetlet.2017.09.042
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4111 / 4114
页数：4
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