Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

被引：70

作者：

Weng, Zhiqiang ^{[1
]}

Li, Huaifeng ^{[2
,3
]}

He, Weiming ^{[1
]}

Yao, Liang-Feng ^{[2
,3
]}

Tan, Jianwei ^{[1
]}

Chen, Jinfa ^{[1
]}

Yuan, Yaofeng ^{[1
]}

Huang, Kuo-Wei ^{[2
,3
]}

机构：

[1] Fuzhou Univ, Dept Chem, Fuzhou 350108, Fujian, Peoples R China

[2] King Abdullah Univ Sci & Technol, KAUST Catalysis Ctr, Thuwal 239556900, Saudi Arabia

[3] King Abdullah Univ Sci & Technol, Div Chem & Life Sci & Engn, Thuwal 239556900, Saudi Arabia

来源：

TETRAHEDRON | 2012年 / 68卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Copper catalyst; Terminal alkyne; Trifluoromethylation reaction; OXIDATIVE TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; FACILE SYNTHESIS; ARYL IODIDES; FLUORINE; PALLADIUM; CHEMISTRY; AGENTS;

D O I：

10.1016/j.tet.2011.12.085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalytic process for trifluoromethylation of terminal alkynes with Togni's reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2527 / 2531

页数：5

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