Breastfeeding protects against acute gastroenteritis due to rotavirus in infants

被引:39
|
作者
Plenge-Boenig, Anita [2 ]
Soto-Ramirez, Nelis [1 ]
Karmaus, Wilfried [1 ]
Petersen, Gudula [3 ]
Davis, Susan [4 ]
Forster, Johannes [5 ]
机构
[1] Univ S Carolina, Dept Epidemiol, Columbia, SC 29208 USA
[2] Inst Hyg & Environm, Hamburg, Germany
[3] Wyeth Pharma Germany, Munster, Germany
[4] Michigan State Univ, E Lansing, MI 48824 USA
[5] St Josefs Hosp, Freiburg, Germany
关键词
Acute gastroenteritis; Breastfeeding; Rotavirus; Infants; ENTERIC PATHOGENS; RISK-FACTORS; US CHILDREN; DISEASE; INFECTIONS; DIARRHEA; PREVENTION; EPIDEMIOLOGY; BURDEN; AGE;
D O I
10.1007/s00431-010-1245-0
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
To assess whether breastfeeding protects against acute gastroenteritis (AGE) due to rotavirus (RV) infection compared to RV-negative AGE (RV-) in children age 0-12 months. Data from a community-based study of children with AGE from 30 pediatric practices in Germany, Switzerland, and Austria were evaluated. A case-control design was conducted with RV-positive AGE (RV+) cases and RV- AGE as controls. Odds ratios and 95% confidence intervals were estimated using log-linear regression models adjusting for child's age, family size, number of siblings, child care attendance, and nationality. A total of 1,256 stool samples were collected from infants with AGE; 315 (25%) were RV+ and 941 RV-. Being breastfed in the period of disease inception reduced the risk of AGE due to RV+ (OR, 0.53; 95% CI, 0.37-0.76). In infants 0-6 months of age, the protective effect was stronger (OR, 0.33; 95% CI, 0.19-0.55) than in 7-12-month-old children. Our study adds to the evidence of a protective concurrent effect of breastfeeding against rotavirus infection in infants, particularly in children 6 months and younger. Breastfeeding is important to diminish rotavirus-related gastroenteritis in infants before vaccination can be introduced.
引用
收藏
页码:1471 / 1476
页数:6
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