A conceptual and practical overview of cDNA microarray technology: implications for basic and clinical sciences

被引：5

作者：

de Mello-Coelho, V ^{[1
]}

Hess, KL ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Histol & Embriol, BR-21941590 Rio De Janeiro, Brazil

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 2005年 / 38卷 / 10期

关键词：

biotechnology; cDNA microarray; gene expression; genomics;

D O I：

10.1590/S0100-879X2005001000011

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

cDNA microarray is an innovative technology that facilitates the analysis of the expression of thousands of genes simultaneously. The utilization of this methodology, which is rapidly evolving, requires a combination of expertise from the biological, mathematical and statistical sciences. In this review, we attempt to provide an overview of the principles of cDNA microarray technology, the practical concerns of the analytical processing of the data obtained, the correlation of this methodology with other data analysis methods such as immunohistochemistry in tissue microarrays, and the cDNA microarray application in distinct areas of the basic and clinical sciences.

引用

页码：1543 / 1552

页数：10