Vitamin D and cancer: antineoplastic effects of 1α,25(OH)2-vitamin D3

被引：0
|
作者：
Gonzalez Pardo, Veronica
Boland, Ricardo
Russo de Boland, Ana [1 ]
机构：
[1] Univ Nacl Sur, Dept Biol Bioquim & Farm, RA-8000 Bahia Blanca, Buenos Aires, Argentina
来源：
MEDICINA-BUENOS AIRES | 2012年 / 72卷 / 02期
关键词：
Vitamin D; cancer; antineoplastic mechanism; D-RECEPTOR VDR; PROTEIN-KINASE-C; 1,25-DIHYDROXYVITAMIN D-3; PROSTATE-CANCER; GENE-EXPRESSION; COLON-CANCER; D ANALOGS; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; MONOCYTIC DIFFERENTIATION; MAMMARY CARCINOGENESIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Vitamin D and cancer: antineoplastic effects of 1 alpha,25(OH)(2)-vitamin D-3. The hormonal form of vitamin D, 1 alpha,25(OH)(2)-vitamin D-3 (1 alpha,25(OH)(2)D-3), in addition of playing a central role in the control of calcium homeostasis in the body, regulates the growth and differentiation of different cell types, including cancer cells. At present several epidemiologic and clinical studies investigate the effect of the hormone in these cells due to the interest in the therapeutic use of 1 alpha,25(OH)(2)D-3 and analogues with less calcemic activity for prevention or treatment of cancer. This review describes vitamin D endocrine system, its mechanism of action, its antineoplastic activity and provides information about the latest advances in the study of new hormone analogues with less calcemic activity for cancer treatment.
引用
收藏
页码：143 / 149
页数：7
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