Vitamin D and cancer: antineoplastic effects of 1α,25(OH)2-vitamin D3

被引：0
|
作者：
Gonzalez Pardo, Veronica
Boland, Ricardo
Russo de Boland, Ana [1 ]
机构：
[1] Univ Nacl Sur, Dept Biol Bioquim & Farm, RA-8000 Bahia Blanca, Buenos Aires, Argentina
来源：
MEDICINA-BUENOS AIRES | 2012年 / 72卷 / 02期
关键词：
Vitamin D; cancer; antineoplastic mechanism; D-RECEPTOR VDR; PROTEIN-KINASE-C; 1,25-DIHYDROXYVITAMIN D-3; PROSTATE-CANCER; GENE-EXPRESSION; COLON-CANCER; D ANALOGS; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; MONOCYTIC DIFFERENTIATION; MAMMARY CARCINOGENESIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Vitamin D and cancer: antineoplastic effects of 1 alpha,25(OH)(2)-vitamin D-3. The hormonal form of vitamin D, 1 alpha,25(OH)(2)-vitamin D-3 (1 alpha,25(OH)(2)D-3), in addition of playing a central role in the control of calcium homeostasis in the body, regulates the growth and differentiation of different cell types, including cancer cells. At present several epidemiologic and clinical studies investigate the effect of the hormone in these cells due to the interest in the therapeutic use of 1 alpha,25(OH)(2)D-3 and analogues with less calcemic activity for prevention or treatment of cancer. This review describes vitamin D endocrine system, its mechanism of action, its antineoplastic activity and provides information about the latest advances in the study of new hormone analogues with less calcemic activity for cancer treatment.
引用
收藏
页码：143 / 149
页数：7
相关论文
共 50 条
  • [1] Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3
    Norman, AW
    Okamura, WH
    Bishop, JE
    Henry, HL
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2002, 197 (1-2) : 1 - 13
  • [2] Identification of 7-dehydrocholesterol, vitamin D3, 25(OH)-vitamin D3 and 1,25(OH)2-vitamin D3 in Solanum glaucophyllum cultures grown in absence of light
    Curino, A
    Skliar, M
    Boland, R
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1998, 1425 (03): : 485 - 492
  • [3] ACTION OF 1,25(OH)2-VITAMIN D3 AND 1ALPHA(OH)-VITAMIN D3 ON MAGNESIUM-METABOLISM IN MAN
    BRICKMAN, AS
    HARTENBOWER, DL
    NORMAN, AW
    COBURN, JW
    CLINICAL RESEARCH, 1975, 23 (03): : A315 - A315
  • [4] Beneficial Impact of Inhaled 25(OH)-Vitamin D3 and 1,25(OH)2-Vitamin D3 on Pulmonary Response in the Murine Model of Hypersensitivity Pneumonitis
    Lemieszek, Marta Kinga
    Chojnacki, Michal
    Pasnik, Iwona
    Gawrys, Wiktoria
    Wilczynska, Alicja
    Lesniowska, Ilona
    Anisiewicz, Jakub
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (19)
  • [5] 1,25(OH)2 vitamin D3 -: The vitamin D hormone
    Jakob, F
    INTERNIST, 1999, 40 (04): : 414 - 430
  • [6] Electrical responses to 1α,25(OH)2-vitamin D3 and their physiological significance in osteoblasts
    Zanello, LP
    Norman, AW
    STEROIDS, 2004, 69 (8-9) : 561 - 565
  • [7] Modulation of tyrosine phosphorylation signalling pathways by 1α,25(OH)2-vitamin D3
    Boland, R
    Buitrago, C
    De Boland, AR
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2005, 16 (06): : 280 - 287
  • [8] 1alpha,25(OH)2-vitamin D3 effects in cellular cycle of Rhabdomyosarcoma cells
    Lrazoqui, A. P.
    Buitrago, C. C.
    BONE, 2017, 105 : 300 - 300
  • [9] 1-BETA,25(OH)2-VITAMIN D3 IS AN ANTAGONIST OF 1-ALPHA,25(OH)2-VITAMIN D3 STIMULATED TRANSCALTACHIA (THE RAPID HORMONAL-STIMULATION OF INTESTINAL CALCIUM-TRANSPORT)
    NORMAN, AW
    NEMERE, I
    MURALIDHARAN, KR
    OKAMURA, WH
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 189 (03) : 1450 - 1456
  • [10] Regulation of Rat Ileal NHE3 by 1,25(OH)2-Vitamin D3
    R. Gill
    T.M. Nazir
    R. Wali
    M. Sitrin
    T.A. Brasitus
    K. Ramaswamy
    P.K. Dudeja
    Digestive Diseases and Sciences, 2002, 47 : 1169 - 1174
12345