Magnetic immunoassays utilizing magnetic markers and a high-TC SQUID

被引:23
|
作者
Enpuku, K [1 ]
Inoue, K
Soejima, K
Yoshinaga, K
Kuma, H
Hamasaki, N
机构
[1] Kyushu Univ, Res Inst Superconductor Sci & Syst, Fukuoka 8128581, Japan
[2] Kyushu Inst Technol, Dept Appl Chem, Kitakyushu, Fukuoka 8048550, Japan
[3] Kyushu Univ, Dept Med Sci, Fukuoka 8128582, Japan
关键词
high-T-C SQUID; immunoassay; magnetic nanoparticle; remanence;
D O I
10.1109/TASC.2005.849991
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Magnetic immunoassays utilizing magnetic markers and a high-T-c SQUID have been performed. We first showed a design of the SQUID for the sensitive detection of the magnetic signal from the marker, where the spatial distribution of the signal field was taken into account. Using the design, we can obtain the relationship between the magnetization of the maker and the signal flux detected with the SQUID. This relationship is important for quantitative evaluation of the immunoassay. Next, we detected biological materials called IgE with a remanence measurement method, where a marker made of Fe3O4 particles with diameter of 25 nm was used. We showed that 2 atto-mol of IgE can be detected, which shows high sensitivity of the present method.
引用
收藏
页码:660 / 663
页数:4
相关论文
共 50 条
  • [41] Liquid-Phase Detection of Biological Targets with Magnetic Markers and High Tc SQUID
    Uchida, S.
    Higuchi, Y.
    Ueoka, Y.
    Yoshida, T.
    Enpuku, K.
    Adachi, S.
    Tanabe, K.
    Tsukamoto, A.
    2013 IEEE 14TH INTERNATIONAL SUPERCONDUCTIVE ELECTRONICS CONFERENCE (ISEC), 2013,
  • [42] Development of a high-Tc SQUID cryo-system for the measurement of a remanent magnetic field of rock
    Tanaka, S
    Shimizu, R
    Saito, Y
    Shin, K
    IEICE TRANSACTIONS ON ELECTRONICS, 2000, E83C (01) : 44 - 48
  • [43] Absolute determination of Co magnetic moments:: Ultrahigh-vacuum high-Tc SQUID magnetometry
    Ney, A
    Poulopoulos, P
    Farle, M
    Baberschke, K
    PHYSICAL REVIEW B, 2000, 62 (17): : 11336 - 11339
  • [44] Evaluation of thermo responsive magnetic nano-particles for high-Tc SQUID bio application
    Tanaka, S.
    Toriyabe, C.
    Torii, Y.
    Hatsukade, Y.
    Eki, T.
    Katsura, S.
    Ohnishi, N.
    Wan, J.
    Yang, S.
    Zhang, Y.
    PHYSICA C-SUPERCONDUCTIVITY AND ITS APPLICATIONS, 2007, 463 : 1029 - 1033
  • [45] Effect of a static magnetic field on a slotted high-Tc SQUID magnetometer without a flux dam
    Yokosawa, K
    Oyama, H
    Kuriki, S
    Suzuki, D
    Tsukada, K
    Matsuda, M
    IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 2001, 11 (01) : 1335 - 1338
  • [46] Development of high-Tc SQUID microscope
    Sata, K
    Ishida, T
    PHYSICA B-CONDENSED MATTER, 2003, 329 : 1502 - 1503
  • [47] Development of integrated AC-DC magnetometer using high-Tc SQUID for magnetic properties evaluation of magnetic nanoparticles in solution
    Saari, Mohd Mawardi
    Takagi, Ryuki
    Kusaka, Toki
    Ishihara, Yuichi
    Tsukamoto, Yuya
    Sakai, Kenji
    Kiwa, Toshihiko
    Tsukada, Keiji
    11TH EUROPEAN CONFERENCE ON APPLIED SUPERCONDUCTIVITY (EUCAS2013), PTS 1-4, 2014, 507
  • [48] MAGNETIC FORCE MICROSCOPY ON HIGH-TC SUPERCONDUCTORS
    MOSER, A
    HUG, HJ
    FRITZ, O
    PARASHIKOV, I
    GUNTHERODT, HJ
    JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 1994, 12 (03): : 1586 - 1590
  • [49] PROGRESS IN HIGH-TC MAGNETIC SENSORS AND THEIR APPLICATIONS
    DONALDSON, GB
    BOWMAN, RM
    COCHRAN, A
    KIRK, KJ
    PEGRUM, CM
    MACFARLANE, JC
    PHYSICA SCRIPTA, 1992, T45 : 34 - 40
  • [50] MAGNETIC HYSTERESIS PHENOMENA IN HIGH-TC SUPERCONDUCTORS
    SEBEK, J
    STEHNO, J
    SAFRATA, S
    SRAMEK, J
    HAVELA, L
    SECHOVSKY, V
    SMETANA, Z
    SVOBODA, P
    VALVODA, V
    CZECHOSLOVAK JOURNAL OF PHYSICS, 1987, 37 (05) : 660 - 664