Immune Consequences of Endothelial Cells' Activation and Dysfunction During Sepsis

被引：44

作者：

Pons, Stephanie ^{[1
]}

Arnaud, Marine ^{[1
]}

Loiselle, Maud ^{[1
]}

Arrii, Eden ^{[1
]}

Azoulay, Elie ^{[2
]}

Zafrani, Lara ^{[1
,2
]}

机构：

[1] St Louis Teaching Hosp, INSERM U976, 1 Ave Claude Vellefaux, F-75010 Paris, France

[2] St Louis Teaching Hosp, Med Intens Care Unit, 1 Ave Claude Vellefaux, F-75010 Paris, France

来源：

CRITICAL CARE CLINICS | 2020年 / 36卷 / 02期

关键词：

Endothelial dysfunction; Hemostasis; Barrier function; Sepsis; Innate immunity; Adaptive immunity; WEIBEL-PALADE BODIES; VON-WILLEBRAND-FACTOR; NF-KAPPA-B; NITRIC-OXIDE; IFN-GAMMA; BACTERIAL LIPOPOLYSACCHARIDE; LEUKOCYTE TRANSMIGRATION; PLATELET ACTIVATION; GROWTH-FACTOR; TNF-ALPHA;

D O I：

10.1016/j.ccc.2019.12.001

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The vascular endothelium provides a direct interface between circulating blood cells and parenchymal cells. Thus, it has a key role in vasomotor tone regulation, primary hemostasis, vascular barrier, and immunity. In the case of systemic inflammation, endothelial cell (EC) activation initiates a powerful innate immune response to eliminate the pathogen. In some specific conditions, ECs may also contribute to the activation of adaptive immunity and the recruitment of antigen-specific lymphocytes. However, the loss of EC functions or an exaggerated activation of ECs during sepsis can lead to multiorgan failure.

引用

页码：401 / +

页数：14

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