Immune Consequences of Endothelial Cells' Activation and Dysfunction During Sepsis

被引:44
|
作者
Pons, Stephanie [1 ]
Arnaud, Marine [1 ]
Loiselle, Maud [1 ]
Arrii, Eden [1 ]
Azoulay, Elie [2 ]
Zafrani, Lara [1 ,2 ]
机构
[1] St Louis Teaching Hosp, INSERM U976, 1 Ave Claude Vellefaux, F-75010 Paris, France
[2] St Louis Teaching Hosp, Med Intens Care Unit, 1 Ave Claude Vellefaux, F-75010 Paris, France
关键词
Endothelial dysfunction; Hemostasis; Barrier function; Sepsis; Innate immunity; Adaptive immunity; WEIBEL-PALADE BODIES; VON-WILLEBRAND-FACTOR; NF-KAPPA-B; NITRIC-OXIDE; IFN-GAMMA; BACTERIAL LIPOPOLYSACCHARIDE; LEUKOCYTE TRANSMIGRATION; PLATELET ACTIVATION; GROWTH-FACTOR; TNF-ALPHA;
D O I
10.1016/j.ccc.2019.12.001
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The vascular endothelium provides a direct interface between circulating blood cells and parenchymal cells. Thus, it has a key role in vasomotor tone regulation, primary hemostasis, vascular barrier, and immunity. In the case of systemic inflammation, endothelial cell (EC) activation initiates a powerful innate immune response to eliminate the pathogen. In some specific conditions, ECs may also contribute to the activation of adaptive immunity and the recruitment of antigen-specific lymphocytes. However, the loss of EC functions or an exaggerated activation of ECs during sepsis can lead to multiorgan failure.
引用
收藏
页码:401 / +
页数:14
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