Recent Advances in Metal-Organic Frameworks for Biomacromolecule Sensing

Metal-organic frameworks (MOFs) are emerging class of ordered porous materials consisting of metal clusters and organic ligands. High porosity, adjustable topology, composition and structural diversity have earned MOFs extensive popularity in various fields, including biosensing. This review focuses on understanding the role of MOFs in biosensing, mainly as efficient signal probes, nanozymes and nanocarriers. It also provides the recent advances of MOFs in sensing biomacromolecules such as protein, peptide, DNA, RNA and polysaccharide. In addition, the challenge, and perspectives, of MOFs in biosensing are presented, based on our opinion.