Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp SCSIO 01127

被引：71

作者：

Niu, Siwen ^{[1
,2
]}

Li, Sumei ^{[1
]}

Chen, Yuchan ^{[3
]}

Tian, Xinpeng ^{[1
]}

Zhang, Haibo ^{[1
]}

Zhang, Guangtao ^{[1
]}

Zhang, Weimin ^{[3
]}

Yang, Xiaohong ^{[2
]}

Zhang, Si ^{[1
]}

Ju, Jianhua ^{[1
]}

Zhang, Changsheng ^{[1
]}

机构：

[1] Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China

[2] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R China

[3] Guangdong Inst Microbiol, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2011年 / 64卷 / 11期

基金：

美国国家科学基金会;

关键词：

antimicrobial; cytotoxicity; lobophorins; marine Streptomyces; South China Sea; spirotetronate antibiotics; SP NOV; PHYSICOCHEMICAL PROPERTIES; GEN; NOV; SEDIMENT; PRODUCTS;

D O I：

10.1038/ja.2011.78

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The strain SCSIO 01127, isolated from the South China Sea sediment, was identified as a member of Streptomyces by the 16S rDNA sequence analysis. Two new spirotetronate antibiotics lobophorins E (1) and F (2), along with two known analogs lobophorins A (3) and B (4), were isolated from Streptomyces sp. SCSIO 01127. Their structures were elucidated on the basis of detailed IR, NMR and MS spectroscopic analyses. The new compound lobophorin F (2) showed antibacterial activities against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 with MIC values of 8 mu g ml(-1) for both the strains, better than that of lobophorin B (4). Lobophorin F (2) also displayed better cytotoxic activities than lobophorin B (4), with IC50 of 6.82, 2.93 and 3.16 mu M against SF-268, MCF-7 and NCI-H460, respectively. The Journal of Antibiotics (2011) 64, 711-716; doi:10.1038/ja.2011.78; published online 7 September 2011

引用

页码：711 / 716

页数：6

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