Activation-induced cytidine deaminase structure and functions: A species comparative view

被引：31
|
作者：
Barreto, Vasco M. [1 ]
Magor, Brad G. [2 ]
机构：
[1] Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal
[2] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E5, Canada
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2011年 / 35卷 / 09期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Activation-induced cytidine deaminase; AID; Immunoglobulin; Somatic hypermutation; Class switch recombination; Evolution; Review; CLASS-SWITCH RECOMBINATION; IMMUNOGLOBULIN HEAVY-CHAIN; DNA-POLYMERASE-ETA; SINGLE-STRANDED-DNA; PROTEIN-KINASE-A; VARIABLE LYMPHOCYTE RECEPTORS; SOMATIC HYPERMUTATION; B-CELL; ANTIBODY DIVERSIFICATION; GENE CONVERSION;
D O I：
10.1016/j.dci.2011.02.005
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
In the ten years since the discovery of activation-induced cytidine deaminase (AID) there has been considerable effort to understand the mechanisms behind this enzyme's ability to target and modify immunoglobulin genes leading to somatic hypermutation and class switch recombination. While the majority of research has focused on mouse and human models of AID function, work on other species, from lamprey to rabbit and sheep, has taught us much about the scope of functions of the AID mutator. This review takes a species-comparative approach to what has been learned about the AID mutator enzyme and its role in humoral immunity. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：991 / 1007
页数：17
相关论文
共 50 条
  • [21] Post-translational regulation of activation-induced cytidine deaminase
    Basu, Uttiya
    Franklin, Andrew
    Alt, Frederick W.
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2009, 364 (1517) : 667 - 673
  • [22] Aberrant expression of activation-induced cytidine deaminase (AID) and hepatocarcinogenesis
    Kou, Tadayuki
    Marusawa, Hiroyuki
    Kinoshita, Kazuo
    Okazaki, Il-Mi
    Ueda, Yoshihide
    Kodama, Yuzo
    Endo, Yoko
    Haga, Hironori
    Ikai, Iwao
    Chiba, Tsutomu
    GASTROENTEROLOGY, 2006, 130 (04) : A795 - A795
  • [23] Involvement of activation-induced cytidine deaminase in skin cancer development
    Nonaka, Taichiro
    Toda, Yoshinobu
    Hiai, Hiroshi
    Uemura, Munehiro
    Nakamura, Motonobu
    Yamamoto, Norio
    Asato, Ryo
    Hattori, Yukari
    Bessho, Kazuhisa
    Minato, Nagahiro
    Kinoshita, Kazuo
    JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (04): : 1367 - 1382
  • [24] Molecular characterization of Pleurodeles waltl activation-induced cytidine deaminase
    Bascove, Matthieu
    Frippiat, Jean-Pol
    MOLECULAR IMMUNOLOGY, 2010, 47 (7-8) : 1640 - 1649
  • [25] DOWN-REGULATION OF ACTIVATION-INDUCED CYTIDINE DEAMINASE BY CURCUMIN
    Sugiyama, T.
    Zaidi, S. F.
    HELICOBACTER, 2011, 16 : 91 - 91
  • [26] The double-edged sword of activation-induced cytidine deaminase
    Wu, XS
    Geraldes, P
    Platt, JL
    Cascalho, M
    JOURNAL OF IMMUNOLOGY, 2005, 174 (02): : 934 - 941
  • [27] Expression of activation-induced cytidine deaminase decreases throughout the life
    Radu, DL
    Kodera, T
    Bona, C
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2003, 7 (02) : 141 - 145
  • [28] Association of Polymorphisms of Activation-Induced Cytidine Deaminase with Ankylosing Spondylitis
    Shim, Seung Cheol
    Yool, In-Seol
    Park, Chan Keol
    Kim, Ji-Young
    Kim, Young Mo
    Sheen, Dong-Hyuk
    Park, Seok-Rae
    ARTHRITIS & RHEUMATOLOGY, 2016, 68
  • [29] Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
    Martin, Alberto
    Bardwell, Philip D.
    Woo, Caroline J.
    Fan, Manxia
    Shulman, Marc J.
    Scharff, Matthew D.
    2002, Macmillan Magazines Ltd (415)
  • [30] Role of activation-induced cytidine deaminase in the progression of follicular lymphoma
    Shikata, Hisaharu
    Yakushijin, Yoshihiro
    Matsushita, Natsuki
    Sakai, Akira
    Sugita, Atsuro
    Nakamura, Naoya
    Yamanouchi, Jun
    Azuma, Taichi
    Hato, Takaaki
    Yasukawa, Masaki
    CANCER SCIENCE, 2012, 103 (03) : 415 - 421
12345