One-pot three-component synthesis of 1,2,3-triazoles using magnetic NiFe2O4-glutamate-Cu as an efficient heterogeneous catalyst in water

A novel magnetic NiFe2O4 supported glutamate-copper catalyst was prepared in a convenient and ecofriendly manner and characterized using FTIR, XRD, EDX, TEM, SEM, XPS and VSM. This magnetic catalyst exhibited excellent catalytic activity for the synthesis of a wide variety of 1,4-disubstituted-1,2,3-triazoles via one-pot three-component click reactions of sodium azide, non-activated terminal alkynes, and different azide precursors such as epoxides, benzyl chlorides, and aryl boronic acids at room temperature in water. This procedure has some advantages such as an aqueous reaction medium, ambient reaction conditions, high yields, wide substrate scope, easy separation of the catalyst using an external magnet and efficient recycling.