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- [31] Nuclear Exclusion of TET1 Is Associated with Loss of 5-Hydroxymethylcytosine in IDH1 Wild-Type GliomasAMERICAN JOURNAL OF PATHOLOGY, 2012, 181 (02): : 675 - 683Mueller, Tim论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyGessi, Marco论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyWaha, Anke论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyIsselstein, Lukas Jan论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyLuxen, Daniel论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyFreihoff, Dorothee论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyFreihoff, Johannes论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyBecker, Albert论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanySimon, Matthias论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Dept Neurosurg, D-53105 Bonn, Germany Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyHammes, Jennifer论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyDenkhaus, Dorota论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, Germanyzur Muehlen, Anja论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyPietsch, Torsten论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, GermanyWaha, Andreas论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn, Med Ctr, Dept Neuropathol, Sigmund Freud Str 25, D-53105 Bonn, Germany
- [32] DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomasAGING-US, 2020, 12 (24): : 24995 - 25004Liang, Tingyu论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R China Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R ChinaZhou, Xingang论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Ditan Hosp, Dept Pathol, Beijing 100015, Peoples R China Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R ChinaLi, Peiliang论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R China Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R ChinaYou, Gan论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R ChinaWang, Fang论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R China Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R ChinaWang, Peng论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Ditan Hosp, Dept Pathol, Beijing 100015, Peoples R China Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R ChinaFeng, Enshan论文数: 0 引用数: 0 h-index: 0机构: Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R China Capital Med Univ, Beijing Ditan Hosp, Dept Neurosurg, Beijing 100015, Peoples R China
- [33] OPTIMIZATION OF DEMETHYLATING THERAPY FOR IDH1 MUTANT GLIOMASNEURO-ONCOLOGY, 2014, 16Riggins, Gregory J.论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USABorodovsky, Alexandra论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA
- [34] Targeting wild-type IDH1 enhances chemosensitivity in pancreatic cancerCANCER RESEARCH, 2023, 83 (07)Zarei, Mehrdad论文数: 0 引用数: 0 h-index: 0Hajihassani, Omid论文数: 0 引用数: 0 h-index: 0Hue, Jonathan J.论文数: 0 引用数: 0 h-index: 0Graor, Hallie J.论文数: 0 引用数: 0 h-index: 0Hajihassani, Arian论文数: 0 引用数: 0 h-index: 0Loftus, Alexander W.论文数: 0 引用数: 0 h-index: 0Rothermel, Luke D.论文数: 0 引用数: 0 h-index: 0Winter, Jordan M.论文数: 0 引用数: 0 h-index: 0
- [35] Wild-type IDH1 inhibition enhances chemotherapy response in melanomaJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2022, 41 (01)Zarei, Mehrdad论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA Univ Hosp Cleveland Med Ctr, Dept Surg, Div Surg Oncol, 11100 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USAHajihassani, Omid论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USAHue, Jonathan J.论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Cleveland Med Ctr, Dept Surg, Div Surg Oncol, 11100 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USAGraor, Hallie J.论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USALoftus, Alexander W.论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp Cleveland Med Ctr, Dept Surg, Div Surg Oncol, 11100 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USARathore, Moeez论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USAVaziri-Gohar, Ali论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USAAsara, John M.论文数: 0 引用数: 0 h-index: 0机构: Beth Israel Deaconess Med Ctr, Div Signal Transduct, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Mass Spectrometry Core, Boston, MA 02215 USA Harvard Med Sch, Dept Med, Boston, MA 02115 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USAWinter, Jordan M.论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA Univ Hosp Cleveland Med Ctr, Dept Surg, Div Surg Oncol, 11100 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USARothermel, Luke D.论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA Univ Hosp Cleveland Med Ctr, Dept Surg, Div Surg Oncol, 11100 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA
- [36] METABOLIC IMAGING BIOMARKERS FOR MUTANT IDH1 GLIOMASNEURO-ONCOLOGY, 2014, 16Ronen, Sabrina M.论文数: 0 引用数: 0 h-index: 0机构: UCSF, San Francisco, CA USA UCSF, San Francisco, CA USAIzquierdo-Garcia, Jose L.论文数: 0 引用数: 0 h-index: 0机构: UCSF, San Francisco, CA USA UCSF, San Francisco, CA USAChaumeil, Myriam M.论文数: 0 引用数: 0 h-index: 0机构: UCSF, San Francisco, CA USA UCSF, San Francisco, CA USACai, Larry M.论文数: 0 引用数: 0 h-index: 0机构: UCSF, San Francisco, CA USA UCSF, San Francisco, CA USAPhillips, Joanna J.论文数: 0 引用数: 0 h-index: 0机构: UCSF, San Francisco, CA USA UCSF, San Francisco, CA USAPieper, Russell O.论文数: 0 引用数: 0 h-index: 0机构: UCSF, San Francisco, CA USA UCSF, San Francisco, CA USA
- [37] Wild-type and mutated IDH1/2 enzymes and therapy responsesOncogene, 2018, 37 : 1949 - 1960Remco J. Molenaar论文数: 0 引用数: 0 h-index: 0机构: Academic Medical Center,Cancer Center Amsterdam, Department of Medical BiologyJaroslaw P. Maciejewski论文数: 0 引用数: 0 h-index: 0机构: Academic Medical Center,Cancer Center Amsterdam, Department of Medical BiologyJohanna W. Wilmink论文数: 0 引用数: 0 h-index: 0机构: Academic Medical Center,Cancer Center Amsterdam, Department of Medical BiologyCornelis J. F. van Noorden论文数: 0 引用数: 0 h-index: 0机构: Academic Medical Center,Cancer Center Amsterdam, Department of Medical Biology
- [38] Wild-type and mutated IDH1/2 enzymes and therapy responsesONCOGENE, 2018, 37 (15) : 1949 - 1960Molenaar, Remco J.论文数: 0 引用数: 0 h-index: 0机构: Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Biol, Amsterdam, Netherlands Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands Cleveland Clin, Dept Translat Hematol & Oncol Res, Cleveland, OH 44106 USA Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Biol, Amsterdam, NetherlandsMaciejewski, Jaroslaw P.论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin, Dept Translat Hematol & Oncol Res, Cleveland, OH 44106 USA Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Biol, Amsterdam, NetherlandsWilmink, Johanna W.论文数: 0 引用数: 0 h-index: 0机构: Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Biol, Amsterdam, Netherlandsvan Noorden, Cornelis J. F.论文数: 0 引用数: 0 h-index: 0机构: Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Biol, Amsterdam, Netherlands Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Biol, Amsterdam, Netherlands
- [39] Wild-type IDH1 inhibition enhances chemotherapy response in melanomaJournal of Experimental & Clinical Cancer Research, 41Mehrdad Zarei论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterOmid Hajihassani论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterJonathan J. Hue论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterHallie J. Graor论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterAlexander W. Loftus论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterMoeez Rathore论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterAli Vaziri-Gohar论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterJohn M. Asara论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterJordan M. Winter论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer CenterLuke D. Rothermel论文数: 0 引用数: 0 h-index: 0机构: Case Western Reserve University,Case Comprehensive Cancer Center
- [40] BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1NATURE MEDICINE, 2013, 19 (07) : 901 - +Toenjes, Martje论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyBarbus, Sebastian论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyPark, Yoon Jung论文数: 0 引用数: 0 h-index: 0机构: DKFZ, Div Epigenom & Canc Risk Factors, Heidelberg, Germany Ewha Womans Univ, Coll Hlth Sci, Dept Nutr Sci & Food Management, Seoul, South Korea German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyWang, Wei论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanySchlotter, Magdalena论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyLindroth, Anders M.论文数: 0 引用数: 0 h-index: 0机构: DKFZ, Div Epigenom & Canc Risk Factors, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyPleier, Sabrina V.论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany DKFZ, Div Pediat Neurooncol, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyBai, Alfa H. C.论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyKarra, Daniela论文数: 0 引用数: 0 h-index: 0机构: Univ Dusseldorf, Dept Neuropathol, D-40225 Dusseldorf, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyPiro, Rosario M.论文数: 0 引用数: 0 h-index: 0机构: Heidelberg Univ, Inst Pharm & Mol Biotechnol, Dept Bioinformat & Funct Genom, Heidelberg, Germany Heidelberg Univ, Bioquant, Heidelberg, Germany DKFZ, Div Theoret Bioinformat, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyFelsberg, Joerg论文数: 0 引用数: 0 h-index: 0机构: Univ Dusseldorf, Dept Neuropathol, D-40225 Dusseldorf, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyAddington, Adele论文数: 0 引用数: 0 h-index: 0机构: Virginia Polytech Inst & State Univ, Dept Human Nutr Foods & Exercise, Blacksburg, VA USA German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyLemke, Dieter论文数: 0 引用数: 0 h-index: 0机构: DKFZ, Clin Cooperat Unit Neurooncol, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyWeibrecht, Irene论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyHovestadt, Volker论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyRolli, Claudio G.论文数: 0 引用数: 0 h-index: 0机构: Max Planck Inst Intelligent Syst, Dept New Mat & Biosyst, Stuttgart, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyCampos, Benito论文数: 0 引用数: 0 h-index: 0机构: Heidelberg Univ, Div Expt Neurosurg, Heidelberg, Germany Heidelberg Univ, Dept Neurosurg, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyTurcan, Sevin论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanySturm, Dominik论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany DKFZ, Div Pediat Neurooncol, Heidelberg, Germany Univ Heidelberg Hosp, Dept Pediat Oncol Hematol & Immunol, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyWitt, Hendrik论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany DKFZ, Div Pediat Neurooncol, Heidelberg, Germany Univ Heidelberg Hosp, Dept Pediat Oncol Hematol & Immunol, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyChan, Timothy A.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyHerold-Mende, Christel论文数: 0 引用数: 0 h-index: 0机构: Heidelberg Univ, Div Expt Neurosurg, Heidelberg, Germany Heidelberg Univ, Dept Neurosurg, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany论文数: 引用数: h-index:机构:Koenig, Rainer论文数: 0 引用数: 0 h-index: 0机构: Heidelberg Univ, Inst Pharm & Mol Biotechnol, Dept Bioinformat & Funct Genom, Heidelberg, Germany Heidelberg Univ, Bioquant, Heidelberg, Germany DKFZ, Div Theoret Bioinformat, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanySchmidt, Kathrin论文数: 0 引用数: 0 h-index: 0机构: Univ Childrens Hosp, Dept Gen Pediat, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyHull, William-Edmund论文数: 0 引用数: 0 h-index: 0机构: DKFZ, Core Facil, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyPfister, Stefan M.论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany DKFZ, Div Pediat Neurooncol, Heidelberg, Germany Univ Heidelberg Hosp, Dept Pediat Oncol Hematol & Immunol, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyJugold, Manfred论文数: 0 引用数: 0 h-index: 0机构: DKFZ, Core Facil, Small Anim Imaging Ctr, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyHutson, Susan M.论文数: 0 引用数: 0 h-index: 0机构: Virginia Polytech Inst & State Univ, Dept Human Nutr Foods & Exercise, Blacksburg, VA USA German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyPlass, Christoph论文数: 0 引用数: 0 h-index: 0机构: DKFZ, Div Epigenom & Canc Risk Factors, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyOkun, Juergen G.论文数: 0 引用数: 0 h-index: 0机构: Univ Childrens Hosp, Dept Gen Pediat, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyReifenberger, Guido论文数: 0 引用数: 0 h-index: 0机构: Univ Dusseldorf, Dept Neuropathol, D-40225 Dusseldorf, Germany DKFZ, German Canc Consortium DKTK, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyLichter, Peter论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, GermanyRadlwimmer, Bernhard论文数: 0 引用数: 0 h-index: 0机构: German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany German Canc Res Ctr, Div Mol Genet, Heidelberg, Germany