Development of an alternative method to the monkey neurovirulence test for oral poliovirus vaccines

被引：0

作者：

Kaul, A ^{[1
]}

Nübling, M ^{[1
]}

Kempfer, M ^{[1
]}

Schmidt, I ^{[1
]}

Löwer, J ^{[1
]}

机构：

[1] Paul Ehrlich Inst, Abt Virol, D-63225 Langen, Germany

来源：

ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN | 1998年 / 15卷

关键词：

quantitative polymerase chain reaction; oral poliovirus vaccine; monkey neurovirulence test; vaccine associated poliomyelitis; point mutations;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Each oral poliovirus vaccine lot contains attenuated and small amounts of wildtype viruses. Vaccines containing more than a certain limit of of wildtype viruses may cause a vaccine associated poliomyelitis. To provide safe vaccines for humans, each newly manufactured vaccine lot is tested in the monkey neurovirulence test. A certain point mutation on the poliovirus genome has been shown to be responsible for the attenuated phenotype of the vaccine virus. We developed a quantitative PCR method to determine the wildtype proportion at position 472 of poliovirus type 3 genome. This method possibly can be used as an alternative for the monkey, neurovirulence test.

引用

页码：18 / 20

页数：3

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