The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin-induced anaemia in chronic hepatitis C Egyptian patients

被引：6
|
作者：
El Desoky, Ehab S. [1 ]
Abdelhafez, Alaa T. [1 ]
Cusato, Jessica [2 ]
Kamel, Sherif I. [3 ]
Hussein, Abeer M. R. [1 ]
De Nicolo, Amedeo [2 ]
Di Perri, Giovanni [2 ]
D'Avolio, Antonio [2 ]
机构：
[1] Assiut Univ, Dept Pharmacol, Fac Med, Assiut, Egypt
[2] Univ Turin, Amedeo di Savoia Hosp, Infect Dis Unit, Dept Med Sci, Turin, Italy
[3] Assiut Univ, Dept Trop Med & Gastroenterol, Fac Med, Assiut, Egypt
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2017年 / 44卷 / 09期
关键词：
anaemia; ITPA; pharmacogenetics; ribavirin; SLC28A3; SLC29A1; HCV PATIENTS; INFECTION; VARIANTS; SERUM;
D O I：
10.1111/1440-1681.12786
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anaemia among Egyptians with chronic hepatitis C (CHC). Genotyping of three ITPA gene variants and two variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-/ribavirin treatment. The baseline haemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anaemia at 4, 8 and 12weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anaemia after 12weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anaemia during the first 3months of treatment and it is recommended to be assessed before RBV administration.
引用
收藏
页码：965 / 968
页数：4
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