Preparation and Application of Magnetic Propyl Gallate Molecularly Imprinted Polymers in Microchip

3-Methacryloxypropyltrimethoxy silane modified Fe3O4 was employed as the carrier material to prepare core. shell magnetic molecularly imprinted polymers (Fe3O4@SiO2-MIPS) by using a surface molecular imprinting technology with propyl gallate as the template. The magnetic composites were loaded into a microchip and coupled with high. performance liquid chromatography to separate and preconcentrate synthetic phenolic antioxidants (SPAs). The structures of the resulting complex were characterized by scanning electron microscopy, vibrating sample magnetoeter, thermogravimetric analysis/differential thermal gravity analysis, Fourier. transformed infrared spectroscopy and X-ray diffraction spectrometry. Under the optimal conditions (3 mL of sample solution, sample pH of 5. 0, sample flow rate of 0. 5 mL/min, and eluent flow rate of 0. 3 mL/min), the magnetic MIPS displayed enhanced adsorption ability for phenolic antioxidants. The calibration curves showed good linearity with correlation coefficients greater than 0. 9901. Intra. day and inter. day relative standard deviations (RSD) were less than 2. 8% and 3. 5%, respectively. The present method was applied to the determination of phenolic antioxidants in cosmetics samples, illustrating satisfactory recovery (87. 9% - 104. 0%) and reproducibility (RSD less than 3. 7%).