Another Kid on the Block: Long-acting FGF21 Analogue to Treat Dyslipidemia and Fatty Liver

被引:5
|
作者
Yang, Ranyao [1 ,2 ]
Xu, Aimin [1 ,2 ,3 ]
Kharitonenkov, Alexei [4 ]
机构
[1] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Pokfulam, Hong Kong 999077, Peoples R China
[2] Univ Hong Kong, Dept Med, Pokfulam, Hong Kong 999077, Peoples R China
[3] Univ Hong Kong, Dept Pharmacol & Pharm, Pokfulam, L8-39,Lab Block,21 Sassoon Rd, Hong Kong 999077, Peoples R China
[4] AK Biotechnol LLC, 430 Amador Ln, W Palm Beach, FL 33401 USA
来源
关键词
fibroblast growth factor 21 (FGF21); hypertriglyceridemia; obesity; nonalcoholic fatty liver diseases (NAFLD); metabolism;
D O I
10.1210/clinem/dgab686
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E417 / E419
页数:3
相关论文
共 50 条
  • [31] Berberine Ameliorates Fatty Liver Accompanied with Elevated FGF21 on the Levels of Human, Animal, and Cell
    Yan, Hongmei
    Chang, Xinxia
    Bian, Hua
    Xia, Mingfeng
    Yao, Xiuzhong
    Xu, Aimin
    Gao, Xin
    DIABETES, 2015, 64 : A719 - A719
  • [32] Role of plasma FGF21 as a biomarker for nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH)
    Bril, Fernando
    Lomonaco, Romina
    Orsak, Beverly
    Chang, Zhi
    Ortiz-Lopez, Carolina
    Hecht, Joan
    Tio, Fermin
    Cusi, Kenneth
    HEPATOLOGY, 2013, 58 : 487A - 487A
  • [33] Clinical significance of serum FGF21 levels in diagnosing nonalcoholic fatty liver disease early
    Xu, Kai
    He, Bo-Wu
    Yu, Jian-Ling
    Kang, Hui-Min
    Zheng, Ting-Ting
    Chen, Zhi-Yun
    Li, Jian-Shuang
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [34] CVX-343, a Long-Acting FGF21 CovX-Body, Demonstrates Prolonged Anti-Diabetic Efficacy in Diabetic Mouse Models
    Huang, Jie
    Rolzin, Paul
    Osothprarop, Trina F.
    Ishino, Tetsuya
    Wiese, Joe
    Retting, Kelsey
    Del Rosario, Joselyn
    Li, Lingna
    Vu, Calvin
    Matin, Marla J.
    Ainekulu, Zemeda W.
    Kinhikar, Arvind
    Palanki, Moorthy
    Huyghe, Bernard
    Violand, Bernard N.
    Finn, Rory F.
    Woodnutt, Gary
    Lappe, Rodney W.
    Levin, Nancy
    DIABETES, 2011, 60 : A285 - A285
  • [35] YH25724, a novel long-acting GLP-1/FGF21 dual agonist, exhibits marked anti-fibrotic effects in different experimental models of liver fibrosis
    Kim, Dohoon
    Kim, Junhwan
    Kim, Tae Wang
    Hong, Han
    Choi, Hyun
    Yang, Ji-Eun
    Jeong, Da-Na
    Ju, Mi Kyeong
    Seo, Minji
    Kim, Su Kyung
    Park, Ju-Young
    Choi, Byung Hyun
    Kim, Han-Joo
    Ahn, Kyoung Kyu
    Kim, Jong-Gyun
    Bedossa, Pierre
    Ratziu, Vlad
    Oh, Se-Woong
    Choi, Soongyu
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E793 - E793
  • [36] Effect of fatty acids and selected drugs on the albumin binding of a long-acting, acylated insulin analogue
    Kurtzhals, P
    Havelund, S
    Jonassen, I
    Markussen, J
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (12) : 1365 - 1368
  • [37] regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease
    Yueh, Mei-Fei
    He, Feng
    Chen, Chen
    Vu, Catherine
    Tripathi, Anupriya
    Knight, Rob
    Karin, Michael
    Chen, Shujuan
    Tukey, Robert H.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (49) : 31259 - 31266
  • [38] LONG-ACTING INSULIN IS ASSOCIATED WITH PROGRESSION OF LIVER FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
    Seo, Dong Joo
    Lee, David
    Rai, Puja
    Zelman, Sara
    Fan, Gregory Hongyuan
    Malik, Raza
    HEPATOLOGY, 2020, 72 : 1053 - 1053
  • [39] A new long-acting GLP-1 derivative KTP ameliorates hyperglycemia and dyslipidemia and improves pancreas and fatty liver in db/db mice
    Sang YanXia
    Zhou TianHong
    Li HongJian
    Ran YanHong
    Jiang DeQi
    Zheng Fei
    Chen Ying
    Wang CongFeng
    Zou Xin
    CHINESE SCIENCE BULLETIN, 2013, 58 (20): : 2447 - 2453
  • [40] A new long-acting GLP-1 derivative KTP ameliorates hyperglycemia and dyslipidemia and improves pancreas and fatty liver in db/db mice
    SANG YanXia
    ZHOU TianHong
    LI HongJian
    RAN YanHong
    JIANG DeQi
    ZHENG Fei
    CHEN Ying
    WANG CongFeng
    ZOU Xin
    ChineseScienceBulletin, 2013, 58 (20) : 2447 - 2453