Rheumatic Manifestations of Primary and Metastatic Bone Tumors and Paraneoplastic Bone Disease

Bone tumors can simulate a wide range of rheumatic disorders, delaying tumor diagnosis and therefore the probability of cure. This review describes the clinical presentation of primary and metastatic bone tumors, with particular emphasis on differential diagnosis with other musculoskeletal conditions and atypical symptoms that should alert clinicians of an underlying malignancy. In addition, the authors summarize the most common paraneoplastic syndromes affecting bone and how cancer treatment can affect bone health.