Area postrema-lesions increase operant responding to sucrose in rats

被引：4
|
作者：
Miller, CC
Holmes, PV
Garrett, JL
Edwards, GL [1 ]
机构：
[1] Univ Georgia, Coll Vet Med, Dept Physiol & Pharmacol, Athens, GA 30602 USA
[2] Univ Georgia, Dept Psychol, Athens, GA 30602 USA
来源：
NEUROSCIENCE LETTERS | 2005年 / 381卷 / 1-2期
关键词：
food reward; hindbrain; nucleus of the solitary tract; fixed ratio; progressive ratio; food intake;
D O I：
10.1016/j.neulet.2005.02.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rats with lesions of the area postrema (APX) are known to exhibit an enhanced intake of highly palatable foods Such as sweetened condensed milk and cookies. These observations suggest the possibility that APX rats find these foods more rewarding and will work harder to obtain these foods. Sham and APX rats were tested on fixed ratio (FR) and progressive ratio (PR) schedules. APX rats consistently pressed more times to receive sucrose solution and attained both FR 3 and FR 5 criteria significantly faster than sham-lesioned control rats. Furthermore, rats with APX had significantly higher break points than sham-lesioned control rats on a progressive ratio schedule. These results support the hypothesis that rats with lesions of the area postrema will consistently work harder to obtain a highly palatable food reward. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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页码：135 / 138
页数：4
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