Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.

被引:47
|
作者
Longeon, Arlette [1 ]
Copp, Brent R. [2 ]
Quevrain, Elodie [1 ]
Roue, Melanie [1 ]
Kientz, Betty [1 ]
Cresteil, Thierry [3 ]
Petek, Sylvain [4 ]
Debitus, Cecile [4 ]
Bourguet-Kondracki, Marie-Lise [1 ]
机构
[1] Museum Natl Hist Nat, Lab Mol Commun & Adaptat Microorganismes, CNRS, UMR 7245, 57 Rue Cuvier,CP 54, F-75005 Paris, France
[2] Univ Auckland, Dept Chem, Auckland, New Zealand
[3] Ctr Rech Gif, Inst Chim Subst Nat, CNRS, UPR 2301, F-91198 Gif Sur Yvette, France
[4] CNRS, Ctr Polynesien Rech Biodivers Insulaire, UMR 7138, F-98713 Papeete, Tahiti, France
关键词
indole derivatives; bromoindoles; marine sponge; Rhopaloeides odorabile; Hyrtios sp; PLA(2) inhibitor; antioxidant; cytotoxic; RADICAL ABSORBENCY CAPACITY; ALKALOIDS; PLAKOHYPAPHORINES; METABOLITES;
D O I
10.3390/md9050879
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
引用
收藏
页码:879 / 888
页数:10
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